Condition category
Circulatory System
Date applied
09/09/2005
Date assigned
22/11/2005
Last edited
01/02/2010
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Matthew Walters

ORCID ID

Contact details

Department of Medicine & Therapeutics
Western Infirmary
44 Church Street
Glasgow
G11 6NT
United Kingdom
+44 (0)141 211 2821
gcl203@clinmed.gla.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

Study hypothesis

Treatment with xanthine oxydase inhibitor allopurinol will improve cerebrovascular reactivity in patients with subcortical stroke.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Subcortical stroke.

Intervention

3 month allopurinol treatment (300 mg) versus lactose tablet.

Intervention type

Drug

Phase

Not Specified

Drug names

Allopurinol

Primary outcome measures

The change in flow velocity in the middle cerebral artery (MCA) following acetazolomide infusion.

Secondary outcome measures

1. Change in serum urate
2. Recurrent stroke or other cardiac event

Overall trial start date

01/11/2005

Overall trial end date

01/11/2007

Reason abandoned

Eligibility

Participant inclusion criteria

1. Subcortical stroke
2. Index stroke within 2 weeks and 3 months prior to randomisation

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

80

Participant exclusion criteria

1. >70% Internal carotid artery stenosis
2. Coronary artery disease
3. Other significant comorbidity
4. Contraindication to allopurinol
5. Contraindication to acetazolamide
6. Concurrent azathioprine or 6-mercaptopurine therapy
7. Serum creatinine >250 µmol/l
8. Woman of childbearing potential

Recruitment start date

01/11/2005

Recruitment end date

01/11/2007

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Department of Medicine & Therapeutics
Glasgow
G11 6NT
United Kingdom

Sponsor information

Organisation

Greater Glasgow NHS Board/Glasgow University (UK)

Sponsor details

c/o Judith Godden
Administration Building
Western Infirmary
Dumbarton Road
Glasgow
G11 6NT
United Kingdom
+44 (0)141 211 2000
judith.godden@Northglasgow.NHS.Scot.UK

Sponsor type

Government

Website

Funders

Funder type

Charity

Funder name

West Endowment Fund (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19916990

Publication citations

  1. Results

    Dawson J, Quinn TJ, Harrow C, Lees KR, Walters MR, The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial., Br J Clin Pharmacol, 2009, 68, 5, 662-668, doi: 10.1111/j.1365-2125.2009.03497.x.

Additional files

Editorial Notes