Condition category
Not Applicable
Date applied
Date assigned
Last edited
Prospectively registered
Overall trial status
Recruitment status
Not yet recruiting

Plain English Summary

Background and study aims
People who are homeless often have problem drug use which leads to drug overdoses. These can be either fatal or non-fatal. Non-fatal overdoses are picked up on the street, homeless accommodation, Emergency Departments and lots of other places, mostly in and around Glasgow city centre. Glasgow has a particular problem with drug use and overdoses and homelessness. People who are homeless are generally very unwell, with drug addiction being one of many problems.
Over the past 7 years a team called the PHOENIx (Pharmacy Homeless Outreach Engagement Non medical Independent prescribing Rx) comprising NHS pharmacists working in pairs with Simon Community Scotland workers, have met people who are homeless and offered an assessment of their health, drug use, housing, social activities, and benefits. The assessment is followed by the pharmacist treating the patient, referring to other services, and the Simon Community worker assessing benefits, social activities and housing, before addressing all or some of these as required.
Researchers are interested in testing whether the PHOENIx intervention can reduce the chance of people who are homeless overdosing with drugs. To do this properly, they need to run a full scale randomised controlled trial (where participants are allocated to an intervention group or usual care at random), but to enable the test to work properly, they first must check, in a miniature study, whether they can recruit and retain enough people in the trial. They also need to work out whether the intervention runs as planned and whether they can collect enough data to enable a bigger test to proceed.

Who can participate?
Adults who are homeless and have recently experienced a non-fatal drug overdose.

What does the study involve?
All participants will receive a baseline assessment from a researcher. Then participants will be allocated at random to either the intervention group or usual care. People allocated to the intervention group will be offered weekly visits by the PHOENIx team (pharmacist and Simon Community worker) who will assess and help participants with their health, housing, benefits and social prescribing. All of this will be in addition to the care they would normally receive from their GP, nurses, hospitals, social care, voluntary sector, etc. The researchers will not be withdrawing any existing services from participants. Participants in the usual care group will receive the same level of care as usual from all of the services available in health, social and third sector agencies, but will not receive the additional offer of support from the PHOENIx team.

What are the possible benefits and risks of participating?
The PHOENIx team may help people improve their health (physical, mental and addictions) by starting them on treatments (directly or through the patient’s GP/Addictions team), helping them to move into safer, better accommodation, offering activities to enable more fulfilling use of time, and help maximise benefits. There are no risks of participating.

Where is the study run from?
NHS Greater Glasgow and Clyde, Pharmacy and Prescribing Support Unit (UK)

When is the study starting and how long is it expected to run for?
November 2020 to August 2022

Who is funding the study?
The Scottish Government (Drug Deaths Task Force) (UK)

Who is the main contact?
Richard Lowrie

Trial website

Contact information



Primary contact

Dr Richard Lowrie


Contact details

Clarkston Clinic
Busy Road
G76 7AT
United Kingdom
+44 (0)7971827565

Additional identifiers

EudraCT number

Nil known number

Nil known

Protocol/serial number


Study information

Scientific title

Pharmacy Homeless Outreach Engagement Non-medical Independent prescribing Rx (PHOENIx) after drug overdose for people experiencing homelessness: a pilot randomised controlled trial



Study hypothesis

The PHOENIx intervention reduces the risk of drug overdose in people experiencing homelessness; the pilot study examines whether the definitive trial should proceed and if so, how.

Ethics approval

Not provided at time of registration

Study design

Randomized controlled trial

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type


Patient information sheet

Not available in web format


Homelessness, drug overdose


Participants are randomized using a telephone randomization service provided by the University of Birmingham

The intervention group receive weekly visits to the patient in their place of residence or other city centre low threshold venue by pharmacist/nurse independent prescriber plus simon Community Scotland outreach worker. The pair will offer an assessment of physical, mental and addiction problems followed by immediate treatment, prescription of medicines and/or referral with assertive follow up. Housing, benefits and social activities will also be assessed and referral made to a relevant agency.

The usual care group will receive the same level of care as usual from all of the services available in health, social and third sector agencies, but will not receive the additional offer of support from the PHOENIx team.

Total duration of intervention: between 6 and 9 months
Follow-up: 8-11 months after baseline assessment.

Intervention type



Drug names

Primary outcome measure

Achievement of criteria for progression to RCT: recruitment rate recorded as 100 participants consenting to participate by 4 months

Secondary outcome measures

Rate of overdose measured by collecting data from NHS Greater Glasgow and Clyde clinical records from baseline until date of follow up (8-11 months after baseline assessment)

Overall trial start date


Overall trial end date


Reason abandoned (if study stopped)


Participant inclusion criteria

1. Adult
2 .Homeless
3. Drug overdose in the past 6 months

Participant type


Age group




Target number of participants


Participant exclusion criteria

Critically unwell/under the influence and unable to comprehend the request

Recruitment start date


Recruitment end date



Countries of recruitment

United Kingdom

Trial participating centre

NHS Greater Glasgow and Clyde
Glasgow City Centre
G76 7AT
United Kingdom

Sponsor information


NHS Greater Glasgow and Clyde

Sponsor details

Clarkston Clinic
G76 7AT
United Kingdom
+44 (0)7971827565

Sponsor type

Hospital/treatment centre



Funder type


Funder name

The Scottish Government (Drug Deaths Task Force) (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

The researchers plan to publish results in a way that maximises impact if the intervention shows a signal of improvement and the definitive study is worthwhile.

IPD sharing statement
The data will not be available because the researchers have not asked patients to consent to use outside the scope described in the patient information and associated materials approved by the ethics committee (pending).

Intention to publish date


Participant level data

Not expected to be available

Basic results (scientific)

Publication list

Publication citations

Additional files

Editorial Notes

23/11/2020: Trial's existence confirmed by the Scottish Government (Drug Deaths Task Force) (UK).