Condition category
Date applied
Date assigned
Last edited
Retrospectively registered
Overall trial status
Recruitment status
No longer recruiting
Publication status

Plain English Summary

Background and study aims
There are no studies that provide sufficient information on how exercise can influence the quality of patient’s life after resection (removal) of the pancreas due to pancreatic disease, such as cancer. The aim of this study is to find out whether exercise can help in controlling blood glucose levels and oxidative stress after pancreatectomy (surgery to remove the pancreas).

Who can participate?
Adult patients with pancreatic cancer that are fit for surgery.

What does the study involve?
The participants are randomly allocated into one of two groups. All participants have a pancreatectomy. The participants in the exercise group exercise using a static bicycle for 12 weeks. The participants in the control group do not exercise. Blood glucose, HBA1c (glycated haemoglobin, which is a form of haemoglobin that is measured to identify average plasma glucose concentrations in the blood), albumin and the uric acid levels for all participants in both groups are measured every 4 weeks for the duration of the study.

What are the possible benefits and risks of participating?
There are no risks for the participants.

Where is the study run from?
Agios Dimitrios General Hospital (under the control of Aristotle University Thessaloniki)

When is study starting and how long is it expected to run for?
May 2014 to June 2016

Who is funding the study?
Agios Dimitrios General Hospital (Greece)

Who is the main contact?
Dr Anastasios Katsourakis

Trial website

Contact information



Primary contact

Dr Anastasios Katsourakis


Contact details

2 Elenis Zografou str
GR- 54634
+30 2313 322 178

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

The influence of exercise on blood glucose control and the anti-oxidative ability of the blood in patients after pancreatectomy: a randomized controlled trial


EQAP (Exercise and Quality of life After Pancreatectomy)

Study hypothesis

The aim of this study is to investigate whether pancreatectomy helps to control blood glucose after exercise, improves the anti-oxidative ability of the blood in patients and improves patient quality of life.

Ethics approval

Bioethics committee and Deontology, Medical School of Aristotle University Thessaloniki, 29/10/2015, ref: 166/ 29.10.2015

Study design

Interventional single-centre,randomized controlled trial

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type

Quality of life

Patient information sheet

Not available in web format, please use contact details to request a participant information sheet


Pancreatic disease, mainly neoplastic tumors of the pancreas


Participants are randomly allocated to one of two groups, the intervention group and the control group.
Both groups will undergo a pancreatectomy. The surgical procedure will be open and according to the location of the tumor the patient will undergo a Longmire Traverso/Whipple operation (pancreatoduodenectomy) or distal pancreatectomy with or without preservation of the spleen. Four weeks after the operation the participants in the intervention group will start to exercise, which involves 30 minutes on a static bicycle (60% of maximum heart rate) for 12 weeks. The participants in the control group do not start to exercise.

Intervention type



Drug names

Primary outcome measure

Measurement of blood glucose levels, HBA1c, albumin and uric acid, 12 weeks after the initiation of exercise (once every 4 weeks interval)

Secondary outcome measures

Evaluation of the quality of life (QoL) in both groups 12 weeks after the initiation of exercise

Overall trial start date


Overall trial end date


Reason abandoned (if study stopped)


Participant inclusion criteria

Adult patients with pancreatic neoplasms that are fit for surgery

Participant type


Age group




Target number of participants

40 patients

Total final enrolment


Participant exclusion criteria

1. Age >75 years old
2. ASA >2
3. Non resectable pancreatic tumor (according to the guidelines)
4. Pregnancy

Recruitment start date


Recruitment end date



Countries of recruitment


Trial participating centre

Agios Dimitrios General Hospital of Greece
2 Elenis Zografou Street

Sponsor information


Agios Dimitrios General Hospital scientific committee and Aristotle University Thessaloniki

Sponsor details

2 Elenis Zografou str
+30 2313 322 100/178

Sponsor type

Hospital/treatment centre



Funder type

Hospital/treatment centre

Funder name

Agios Dimitrios General Hospital

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

The trialists intend to publish the results immediately after the recruitment of a statistically significant number of patients and about 2 weeks later after the statistical analysis.

IPD sharing statement
The datasets generated during and/or analysed during the current study are/will be available upon request from Tasos Katsourakis ( Type of data that will be shared: all data will be available. When the data will be available: starting 01/10/2017. For how long: no limit. What type of analyses: demographic and surgical details, repeated measures ANOVA for the results. Consent was obtained from all participants, no ethical or legal restrictions.

Intention to publish date


Participant level data

Available on request

Basic results (scientific)

Publication list

1. 2019 results in: (added 11/01/2019)
2. 2019 results in: (added 10/06/2019)

Publication citations

Additional files

Editorial Notes

10/06/2019: Publication reference and total final enrolment added. 11/01/2019: Publication reference added. 14/09/2017: IPD sharing statement added. 04/05/2016: Recruitment and overall study end dates changed from 30/04/2016 to 30/06/2016.