Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
G8317732/G9826520
Study information
Scientific title
Acronym
Study hypothesis
Demonstrate possible reduction in mortality from screening for colorectal cancer
Ethics approval
Not provided at time of registration.
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Cancer
Intervention
Haemoccult faecal occult blood screening test/control
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
Not provided at time of registration.
Secondary outcome measures
Not provided at time of registration.
Overall trial start date
01/01/1984
Overall trial end date
30/09/2009
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Population aged 50-74 years (June 06: changed from 50-75 years)
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
152,000
Participant exclusion criteria
Colorectal cancer within 5 yrs of entry date/GPs discretion
Recruitment start date
01/01/1984
Recruitment end date
30/09/2009
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Section of Surgery
Nottingham
NG7 2UH
United Kingdom
Sponsor information
Organisation
Medical Research Council (MRC) (UK)
Sponsor details
20 Park Crescent
London
W1B 1AL
United Kingdom
+44 (0)20 7636 5422
clinical.trial@headoffice.mrc.ac.uk
Sponsor type
Research council
Website
Funders
Funder type
Government
Funder name
Medical Research Council (UK)
Alternative name(s)
MRC
Funding Body Type
government organisation
Funding Body Subtype
Federal/National Government
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
1. 1996 results in http://www.ncbi.nlm.nih.gov/pubmed/8942775
2. 2002 results in http://www.ncbi.nlm.nih.gov/pubmed/12010887
Publication citations
-
Results
Hardcastle JD, Chamberlain JO, Robinson MH, Moss SM, Amar SS, Balfour TW, James PD, Mangham CM, Randomised controlled trial of faecal-occult-blood screening for colorectal cancer., Lancet, 1996, 348, 9040, 1472-1477, doi: 10.1016/S0140-6736(96)03386-7.
-
Results
Scholefield JH, Moss S, Sufi F, Mangham CM, Hardcastle JD, Effect of faecal occult blood screening on mortality from colorectal cancer: results from a randomised controlled trial., Gut, 2002, 50, 6, 840-844.