Contact information
Type
Scientific
Primary contact
Prof Tom Meade
ORCID ID
Contact details
Non-communicable Disease Epidemiology Unit
London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
tom.meade@lshtm.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
Study hypothesis
That treatment with diuretic or beta-blocker in hypertensive people aged between 65 and 74 reduces risk of stroke, coronary heart disease and death.
Ethics approval
Not provided at time of registration.
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Hypertension
Intervention
Amiloride, hydrochlorothiazide compared with placebo; atenolol compared with placebo.
Intervention type
Drug
Phase
Not Specified
Drug names
Amiloride, hydrochlorothiazide and atenolol
Primary outcome measure
Stroke, coronary events, deaths from all causes.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/03/1982
Overall trial end date
01/03/1987
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Men and women aged 65-74 at recruitment in 226 general practices in the Medical Research Council's General Practice Research Framework. Systolic blood pressure 160-209 mmHg and diastolic pressure less than 115 mmHg.
Participant type
Patient
Age group
Senior
Gender
Both
Target number of participants
4396 participants
Participant exclusion criteria
Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; impaired renal function; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease including malignant hypertension.
Recruitment start date
01/03/1982
Recruitment end date
01/03/1987
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Non-communicable Disease Epidemiology Unit
London
WC1E 7HT
United Kingdom
Sponsor information
Organisation
Sponsor not defined - Record provided by the Medical Research Council (UK)
Sponsor details
20 Park Crescent
London
W1B 1AL
United Kingdom
tom.meade@lshtm.ac.uk
Sponsor type
Not defined
Website
Funders
Funder type
Research council
Funder name
Medical Research Council (UK)
Alternative name(s)
MRC
Funding Body Type
government organisation
Funding Body Subtype
National government
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
1985 results in http://www.ncbi.nlm.nih.gov/pubmed/2861880
Publication citations
-
Results
MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party., Br Med J (Clin Res Ed), 1985, 291, 6488, 97-104.