Condition category
Circulatory System
Date applied
07/09/2005
Date assigned
08/09/2005
Last edited
19/05/2011
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof Tom Meade

ORCID ID

Contact details

Non-communicable Disease Epidemiology Unit
London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
tom.meade@lshtm.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

Study hypothesis

That treatment with diuretic or beta-blocker in hypertensive people aged between 65 and 74 reduces risk of stroke, coronary heart disease and death.

Ethics approval

Not provided at time of registration.

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Hypertension

Intervention

Amiloride, hydrochlorothiazide compared with placebo; atenolol compared with placebo.

Intervention type

Drug

Phase

Not Specified

Drug names

Amiloride, hydrochlorothiazide and atenolol

Primary outcome measures

Stroke, coronary events, deaths from all causes.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/03/1982

Overall trial end date

01/03/1987

Reason abandoned

Eligibility

Participant inclusion criteria

Men and women aged 65-74 at recruitment in 226 general practices in the Medical Research Council's General Practice Research Framework. Systolic blood pressure 160-209 mmHg and diastolic pressure less than 115 mmHg.

Participant type

Patient

Age group

Senior

Gender

Both

Target number of participants

4396 participants

Participant exclusion criteria

Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; impaired renal function; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease including malignant hypertension.

Recruitment start date

01/03/1982

Recruitment end date

01/03/1987

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Non-communicable Disease Epidemiology Unit
London
WC1E 7HT
United Kingdom

Sponsor information

Organisation

Sponsor not defined - Record provided by the Medical Research Council (UK)

Sponsor details

20 Park Crescent
London
W1B 1AL
United Kingdom
tom.meade@lshtm.ac.uk

Sponsor type

Not defined

Website

Funders

Funder type

Research council

Funder name

Medical Research Council (UK)

Alternative name(s)

MRC

Funding Body Type

private sector organisation

Funding Body Subtype

other non-profit

Location

United Kingdom

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1985 results in http://www.ncbi.nlm.nih.gov/pubmed/2861880

Publication citations

  1. Results

    MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party., Br Med J (Clin Res Ed), 1985, 291, 6488, 97-104.

Additional files

Editorial Notes