Randomised placebo controlled trial of antihypertensive agents for the prevention of cardiovascular complications of hypertension
| ISRCTN | ISRCTN13275753 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN13275753 |
| Secondary identifying numbers | N/A |
- Submission date
- 07/09/2005
- Registration date
- 08/09/2005
- Last edited
- 19/05/2011
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Tom Meade
Scientific
Scientific
Non-communicable Disease Epidemiology Unit
London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
United Kingdom
| tom.meade@lshtm.ac.uk |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Treatment |
| Scientific title | |
| Study objectives | That treatment with diuretic or beta-blocker in hypertensive people aged between 65 and 74 reduces risk of stroke, coronary heart disease and death. |
| Ethics approval(s) | Not provided at time of registration. |
| Health condition(s) or problem(s) studied | Hypertension |
| Intervention | Amiloride, hydrochlorothiazide compared with placebo; atenolol compared with placebo. |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Amiloride, hydrochlorothiazide and atenolol |
| Primary outcome measure | Stroke, coronary events, deaths from all causes. |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/03/1982 |
| Completion date | 01/03/1987 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Senior |
| Sex | Both |
| Target number of participants | 4396 participants |
| Key inclusion criteria | Men and women aged 65-74 at recruitment in 226 general practices in the Medical Research Council's General Practice Research Framework. Systolic blood pressure 160-209 mmHg and diastolic pressure less than 115 mmHg. |
| Key exclusion criteria | Secondary hypertension; already on antihypertensive treatment; accepted indication for antihypertensive treatment; myocardial infarction or stroke within previous three months; impaired renal function; presence of angina, intermittent claudication, diabetes, gout, bronchial asthma, serious intercurrent disease including malignant hypertension. |
| Date of first enrolment | 01/03/1982 |
| Date of final enrolment | 01/03/1987 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Non-communicable Disease Epidemiology Unit
London
WC1E 7HT
United Kingdom
WC1E 7HT
United Kingdom
Sponsor information
Sponsor not defined - Record provided by the Medical Research Council (UK)
Not defined
Not defined
20 Park Crescent
London
W1B 1AL
United Kingdom
| tom.meade@lshtm.ac.uk |
Funders
Funder type
Research council
Medical Research Council (UK)
Government organisation / National government
Government organisation / National government
- Alternative name(s)
- Medical Research Council (United Kingdom), UK Medical Research Council, MRC
- Location
- United Kingdom
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 13/07/1985 | Yes | No |
