Contact information
Type
Scientific
Primary contact
Prof Francis Creed
ORCID ID
Contact details
Department of Psychiatry
Manchester Royal Infirmary
Oxford Road
Manchester
M13 9WL
United Kingdom
+44 (0)161 276 5331
Francis.Creed@man.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
NMH10C GE179D
Study information
Scientific title
Acronym
UK700 study
Study hypothesis
Case management has increasingly been the recommended approach to care for the severely mentally ill as reliance on mental hospitals has diminished. An influential series of studies in the USA suggested that intensive case management, with case loads of 1:10-15, was particularly effective with the most severe patients, reducing hospitalisation and improving aspects of outcome. Despite equivocal results from replication studies in the UK and Europe this approach is becoming accepted policy. In this study we carried out a large multicentre investigation which was designed to test the impact of reduced case loads.
The aim of this study was to compare two levels of intensity of case management for patients with psychotic illnesses. Firstly to see if intensive case management reduces hospitalisation and costs. Secondly, to assess which levels of case management are appropriate for which levels of disability in terms of cost and outcome.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Other
Trial type
Other
Patient information sheet
Condition
Schizophrenia and other psychoses
Intervention
Eligible patients were randomly allocated to standard case management (case loads 1:30-35) or intensive case management (case loads 1:10-15).
4 mental health centres in England, 3 in Inner London and 1 in Manchester.
Intervention type
Other
Phase
Not Applicable
Drug names
Primary outcome measure
Clinical symptoms and social functioning were measured at baseline, one years and two years. Hospital use was assessed at two years with subgroup analyses for Afro-Caribbean and the most disabled patients. A range of secondary outcomes based on clinical and social functioning was also assessed.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
30/09/1994
Overall trial end date
30/07/1998
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
708 psychotic patients with histories of repeated hospital admission.
Participant type
Patient
Age group
Not Specified
Gender
Both
Target number of participants
708
Participant exclusion criteria
Does not match inclusion criteria
Recruitment start date
30/09/1994
Recruitment end date
30/07/1998
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Department of Psychiatry
Manchester
M13 9WL
United Kingdom
Sponsor information
Organisation
Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK)
Sponsor details
The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
NHS Mental Health National Research and Development Programme (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
1999 results in http://www.ncbi.nlm.nih.gov/pubmed/10392982
Publication citations
-
Results
Burns T, Creed F, Fahy T, Thompson S, Tyrer P, White I, Intensive versus standard case management for severe psychotic illness: a randomised trial. UK 700 Group., Lancet, 1999, 353, 9171, 2185-2189.