Condition category
Mental and Behavioural Disorders
Date applied
23/01/2004
Date assigned
23/01/2004
Last edited
20/11/2009
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof Francis Creed

ORCID ID

Contact details

Department of Psychiatry
Manchester Royal Infirmary
Oxford Road
Manchester
M13 9WL
United Kingdom
+44 (0)161 276 5331
Francis.Creed@man.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

NMH10C GE179D

Study information

Scientific title

Acronym

UK700 study

Study hypothesis

Case management has increasingly been the recommended approach to care for the severely mentally ill as reliance on mental hospitals has diminished. An influential series of studies in the USA suggested that intensive case management, with case loads of 1:10-15, was particularly effective with the most severe patients, reducing hospitalisation and improving aspects of outcome. Despite equivocal results from replication studies in the UK and Europe this approach is becoming accepted policy. In this study we carried out a large multicentre investigation which was designed to test the impact of reduced case loads.
The aim of this study was to compare two levels of intensity of case management for patients with psychotic illnesses. Firstly to see if intensive case management reduces hospitalisation and costs. Secondly, to assess which levels of case management are appropriate for which levels of disability in terms of cost and outcome.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Other

Trial type

Other

Patient information sheet

Condition

Schizophrenia and other psychoses

Intervention

Eligible patients were randomly allocated to standard case management (case loads 1:30-35) or intensive case management (case loads 1:10-15).
4 mental health centres in England, 3 in Inner London and 1 in Manchester.

Intervention type

Other

Phase

Not Applicable

Drug names

Primary outcome measures

Clinical symptoms and social functioning were measured at baseline, one years and two years. Hospital use was assessed at two years with subgroup analyses for Afro-Caribbean and the most disabled patients. A range of secondary outcomes based on clinical and social functioning was also assessed.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

30/09/1994

Overall trial end date

30/07/1998

Reason abandoned

Eligibility

Participant inclusion criteria

708 psychotic patients with histories of repeated hospital admission.

Participant type

Patient

Age group

Not Specified

Gender

Both

Target number of participants

708

Participant exclusion criteria

Does not match inclusion criteria

Recruitment start date

30/09/1994

Recruitment end date

30/07/1998

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Department of Psychiatry
Manchester
M13 9WL
United Kingdom

Sponsor information

Organisation

Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK)

Sponsor details

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Sponsor type

Government

Website

http://www.doh.gov.uk

Funders

Funder type

Government

Funder name

NHS Mental Health National Research and Development Programme (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1999 results in http://www.ncbi.nlm.nih.gov/pubmed/10392982

Publication citations

  1. Results

    Burns T, Creed F, Fahy T, Thompson S, Tyrer P, White I, Intensive versus standard case management for severe psychotic illness: a randomised trial. UK 700 Group., Lancet, 1999, 353, 9171, 2185-2189.

Additional files

Editorial Notes