Condition category
Not Applicable
Date applied
20/12/2005
Date assigned
20/12/2005
Last edited
14/10/2008
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Jody Martens

ORCID ID

Contact details

Academic Hospital Maastricht
onderzoeker FTTO
BZe VII
P.O. Box 5800
Maastricht
6202 AZ
Netherlands
+31 (0)43 387 7390/7388
jd.martens@caphri.unimaas.nl

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

NTR270

Study information

Scientific title

Acronym

Study hypothesis

We hypothesised that this strategy could lead to a considerable and relevant change of prescribing behaviour in the desired direction.

Ethics approval

Received from the local medical ethics committee

Study design

Cluster randomised, single blind, active controlled, crossover trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

GP practices

Trial type

Diagnostic

Patient information sheet

Condition

GP prescribing behaviour

Intervention

A clustered RCT with incomplete block design was executed in the Maastricht and Eastern-South Limburg region.
Randomisation took place on practice level into two blocks: 25 GPs received reminders on antibiotics and asthma/chronic obstructive pulmonary disease (COPD) prescriptions, 28 GPs received reminders on cholesterol prescriptions. All GPs were told that they were participating in a trial, but they were blind for the fact that they only received part of the prescribing reminders.

A computer-reminder-system with reactive reminders was developed to lead to a change in prescribing behaviour in the desired direction. All relevant prescription was written to a special database. GPs were obliged to register a diagnosis for all patients with asthma/COPD, cholesterol related disease or infections for which antibiotics were prescribed. The diagnosis, anamnesis, prescription information as well as information about the patient and GP in question was written to this database.

The character of the reminders could be less or more persuasive and contained various types of reminders: alternative type of drugs, other doses, alternative drug administration, specific indication, other length of prescribing, not to prescribe anything or refer to specialist.

The guidelines on which the reminders were based were developed by multidisciplinary expert teams. The topics were selected because of high prevalence of the health problems and contained antibiotics, asthma/COPD related drugs and cholesterol lowering drugs.

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

The central measure in our trial: prescription according to the guideline recommendation as a percentage of total prescriptions of that drug in block A and B.

Secondary outcome measures

Other measures are: absolute number of reminders per GP per year/ per total patient contacts per year in block A and B

Overall trial start date

01/10/2003

Overall trial end date

01/10/2006

Reason abandoned

Eligibility

Participant inclusion criteria

One inclusion criterion for inviting GPs to the intervention was using a specific medical information system for GPs called MicroHis.

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

53 GPs

Participant exclusion criteria

Does not comply with the above inclusion criteria

Recruitment start date

01/10/2003

Recruitment end date

01/10/2006

Locations

Countries of recruitment

Netherlands

Trial participating centre

Academic Hospital Maastricht
Maastricht
6202 AZ
Netherlands

Sponsor information

Organisation

Care and Public Health Research Institute (CAPHRI) (The Netherlands)

Sponsor details

University Maastricht
P.O. Box 616
Maastricht
6200 MD
Netherlands
+31 (0)43 388 2446
e.habets@caphri.unimaas.nl

Sponsor type

Research organisation

Website

http://www.caphri.nl/

Funders

Funder type

Other

Funder name

VGZ Eindhoven (The Netherlands)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Funder name

CZ Health Insurance Company (CZ Actief in Gezondheid) (Netherlands)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes