Condition category
Oral Health
Date applied
30/09/2004
Date assigned
30/09/2004
Last edited
29/07/2013
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr G S Griffiths

ORCID ID

Contact details

Periodontology
Periodontology Department
Eastman Dental Institute
256 Gray's Inn Road
London
WC1X 8LD
United Kingdom
+44 (0)20 7 915 1074

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N0263128690

Study information

Scientific title

Acronym

Study hypothesis

Does the use of systemic antibiotics have an adjunctive effect over mechanical cleaning and does it lead to an increase in antibiotics resistance?

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Other

Trial type

Treatment

Patient information sheet

Condition

Periodontology; periodontitis

Intervention

Patients with periodontitis undergoing mechanical cleaning will be randomised to receive
1. Antibiotic
2.. Placebo

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Changes in bleeding on probing, probeable crevice depth and lifetime attachment loss.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/04/2003

Overall trial end date

01/07/2004

Reason abandoned

Eligibility

Participant inclusion criteria

40 patients from Periodontology

Participant type

Patient

Age group

Not Specified

Gender

Both

Target number of participants

40

Participant exclusion criteria

Does not match inclusion criteria

Recruitment start date

01/04/2003

Recruitment end date

01/07/2004

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Periodontology
London
WC1X 8LD
United Kingdom

Sponsor information

Organisation

Department of Health

Sponsor details

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Sponsor type

Government

Website

http://www.dh.gov.uk/Home/fs/en

Funders

Funder type

Hospital/treatment centre

Funder name

University College London Hospitals NHS Trust (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2005 results in http://www.ncbi.nlm.nih.gov/pubmed/16174275

Publication citations

  1. Results

    Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, Tonetti MS, Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial., J. Clin. Periodontol., 2005, 32, 10, 1096-1107, doi: 10.1111/j.1600-051X.2005.00814.x.

Additional files

Editorial Notes