Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0263128690
Study information
Scientific title
Acronym
Study hypothesis
Does the use of systemic antibiotics have an adjunctive effect over mechanical cleaning and does it lead to an increase in antibiotics resistance?
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Other
Trial type
Treatment
Patient information sheet
Condition
Periodontology; periodontitis
Intervention
Patients with periodontitis undergoing mechanical cleaning will be randomised to receive
1. Antibiotic
2.. Placebo
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Changes in bleeding on probing, probeable crevice depth and lifetime attachment loss.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/04/2003
Overall trial end date
01/07/2004
Reason abandoned
Eligibility
Participant inclusion criteria
40 patients from Periodontology
Participant type
Patient
Age group
Not Specified
Gender
Both
Target number of participants
40
Participant exclusion criteria
Does not match inclusion criteria
Recruitment start date
01/04/2003
Recruitment end date
01/07/2004
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Periodontology
London
WC1X 8LD
United Kingdom
Sponsor information
Organisation
Department of Health
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Sponsor type
Government
Website
Funders
Funder type
Hospital/treatment centre
Funder name
University College London Hospitals NHS Trust (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
2005 results in http://www.ncbi.nlm.nih.gov/pubmed/16174275
Publication citations
-
Results
Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, Tonetti MS, Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial., J. Clin. Periodontol., 2005, 32, 10, 1096-1107, doi: 10.1111/j.1600-051X.2005.00814.x.