Condition category
Surgery
Date applied
12/09/2003
Date assigned
12/09/2003
Last edited
01/05/2012
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr R Knaggs

ORCID ID

Contact details

c/o Greg Hobbs
University Department of Anaesthesia
C Floor
East Block
University Hospital
Nottingham
NG7 2UH
United Kingdom
+44 (0)115 924 9924 (41229)

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N0192080394

Study information

Scientific title

Acronym

Study hypothesis

What effect does morphine and tramadol administration after surgery using patient controlled analgesia (PCA) have on gastric emptying?

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Not Specified

Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet

Condition

Signs and Symptoms: Gastric emptying

Intervention

Randomised controlled trial.

Intervention type

Procedure/Surgery

Phase

Not Specified

Drug names

Primary outcome measures

Maximum plasma concentration (Cmax) for paracetamol
Time to reach maximum plasma concentration (Tmax) for paracetamol
Area under the plasma concentration - time curve (AUC) for paracetamol
Plasma concentrations of morphine, M6G and tramadol

Secondary outcome measures

Not provided at time of registration

Overall trial start date

13/09/1999

Overall trial end date

01/09/2000

Reason abandoned

Eligibility

Participant inclusion criteria

Total number of subjects = 40.

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

40

Participant exclusion criteria

Does not meet inclusion criteria

Recruitment start date

13/09/1999

Recruitment end date

01/09/2000

Locations

Countries of recruitment

United Kingdom

Trial participating centre

c/o Greg Hobbs
Nottingham
NG7 2UH
United Kingdom

Sponsor information

Organisation

Department of Health (UK)

Sponsor details

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Sponsor type

Government

Website

http://www.doh.gov.uk

Funders

Funder type

Hospital/treatment centre

Funder name

Nottingham University Hospitals NHS Trust (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 1998 comparison results in http://www.ncbi.nlm.nih.gov/pubmed/9706948

Publication citations

  1. Comparison results

    Crighton IM, Martin PH, Hobbs GJ, Cobby TF, Fletcher AJ, Stewart PD, A comparison of the effects of intravenous tramadol, codeine, and morphine on gastric emptying in human volunteers., Anesth. Analg., 1998, 87, 2, 445-449.

Additional files

Editorial Notes