Condition category
Respiratory
Date applied
29/11/2004
Date assigned
30/11/2004
Last edited
03/08/2007
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Peter Black

ORCID ID

Contact details

Department of Medicine
University of Auckland
Private Bag 92019
Auckland
1001
New Zealand
+64 93737599 ext 89797
pn.black@auckland.ac.nz

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

Study hypothesis

Not provided at time of registration

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Chronic obstructive pulmonary disease

Intervention

N-acetylcysteine 600 mg twice daily or matching placebo.
All participants received standard care including oxygen, nebulised salbutamol, oral prednisone and antibiotics (if indicated).

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Not provided at time of registration

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/06/2001

Overall trial end date

01/10/2001

Reason abandoned

Eligibility

Participant inclusion criteria

Patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease.

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

50

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

01/06/2001

Recruitment end date

01/10/2001

Locations

Countries of recruitment

New Zealand

Trial participating centre

Department of Medicine
Auckland
1001
New Zealand

Sponsor information

Organisation

Health Research Council of New Zealand

Sponsor details

PO Box 5541
Wellesley St
Auckland
1001
New Zealand
+64 93035200
info@hrc.govt.nz

Sponsor type

Government

Website

http://www.hrc.govt.nz/

Funders

Funder type

Government

Funder name

Health Research Council of New Zealand (ref: HRC 01/206)

Alternative name(s)

HRC

Funding Body Type

government organisation

Funding Body Subtype

Federal/National Government

Location

New Zealand

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Results in http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15581425

Publication citations

  1. Results

    Black PN, Morgan-Day A, McMillan TE, Poole PJ, Young RP, Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease [ISRCTN21676344]., BMC Pulm Med, 2004, 4, 13, doi: 10.1186/1471-2466-4-13.

Additional files

Editorial Notes