Contact information
Type
Scientific
Primary contact
Dr Peter Black
ORCID ID
Contact details
Department of Medicine
University of Auckland
Private Bag 92019
Auckland
1001
New Zealand
+64 93737599 ext 89797
pn.black@auckland.ac.nz
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
Study hypothesis
Not provided at time of registration
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Chronic obstructive pulmonary disease
Intervention
N-acetylcysteine 600 mg twice daily or matching placebo.
All participants received standard care including oxygen, nebulised salbutamol, oral prednisone and antibiotics (if indicated).
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
Not provided at time of registration
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/06/2001
Overall trial end date
01/10/2001
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease.
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
50
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/06/2001
Recruitment end date
01/10/2001
Locations
Countries of recruitment
New Zealand
Trial participating centre
Department of Medicine
Auckland
1001
New Zealand
Sponsor information
Organisation
Health Research Council of New Zealand
Sponsor details
PO Box 5541
Wellesley St
Auckland
1001
New Zealand
+64 93035200
info@hrc.govt.nz
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
Health Research Council of New Zealand (ref: HRC 01/206)
Alternative name(s)
HRC
Funding Body Type
government organisation
Funding Body Subtype
National government
Location
New Zealand
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
Publication citations
-
Results
Black PN, Morgan-Day A, McMillan TE, Poole PJ, Young RP, Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease [ISRCTN21676344]., BMC Pulm Med, 2004, 4, 13, doi: 10.1186/1471-2466-4-13.