Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease.

ISRCTN	ISRCTN21676344
DOI	https://doi.org/10.1186/ISRCTN21676344
Protocol serial number	N/A
Sponsor	Health Research Council of New Zealand
Funder	Health Research Council of New Zealand (ref: HRC 01/206)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Dr Peter Black
Scientific

Department of Medicine
University of Auckland
Private Bag 92019
Auckland
1001
New Zealand

Phone	+64 93737599 ext 89797
Email	pn.black@auckland.ac.nz

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	Not provided at time of registration
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Chronic obstructive pulmonary disease
Intervention	N-acetylcysteine 600 mg twice daily or matching placebo. All participants received standard care including oxygen, nebulised salbutamol, oral prednisone and antibiotics (if indicated).
Intervention type	Other
Primary outcome measure(s)	Not provided at time of registration
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	01/10/2001

Participant type(s)	Patient
Age group	Not Specified
Sex
Target sample size at registration	50
Key inclusion criteria	Patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease.
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/06/2001
Date of final enrolment	01/10/2001

Department of Medicine

Auckland
1001
New Zealand

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	Results	06/12/2004		Yes	No