Condition category
Signs and Symptoms
Date applied
08/09/2005
Date assigned
31/10/2005
Last edited
15/07/2010
Prospective/Retrospective
Retrospectively registered
Overall trial status
Stopped
Recruitment status
Stopped

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Paul Jefferson

ORCID ID

Contact details

Department of Anaesthetics
DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom
+44 (0)1387 246246
paul.jefferson@nhs.net

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

A1

Study information

Scientific title

Acronym

Study hypothesis

A bolus of ketamine and magnesium at induction does not improve postoperative analgesia following elective total abdominal hysterectomy.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Pain relief post hysterectomy

Intervention

Please note that as of 15/07/10 this trial was never started.

Randomised controlled trial of ketamine and magnesium versus placebo at induction of anaesthesia.

Intervention type

Drug

Phase

Not Applicable

Drug names

Ketamine, magnesium

Primary outcome measures

To determine if the intervention can reduce the use of morphine postoperatively.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/09/2005

Overall trial end date

30/08/2007

Reason abandoned

Eligibility

Participant inclusion criteria

Adult patients with benign disease, scheduled for hysterectomy and able to give informed consent.

Participant type

Patient

Age group

Adult

Gender

Female

Target number of participants

90

Participant exclusion criteria

1. Midline abdominal incision
2. American Society of Anesthesiologists (ASA) >3
3. Age >75 years
4. Long-term use of opioid mediation
5. History of chronic pain syndromes
6. Patients taking antipsychotic medication
7. Major renal or hepatic dsyfunction
8. Neuromuscular disease
9. Surgery - midline incision

Recruitment start date

01/09/2005

Recruitment end date

30/08/2007

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Department of Anaesthetics
Dumfries
DG1 4AP
United Kingdom

Sponsor information

Organisation

NHS Dumfries and Galloway (UK)

Sponsor details

RDSU
DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom
+44 (0)1387 241113
j.lawrence@dgri.scot.nhs.uk

Sponsor type

Government

Website

Funders

Funder type

Government

Funder name

NHS Dumfries and Galloway (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes