Contact information
Type
Scientific
Primary contact
Dr Paul Jefferson
ORCID ID
Contact details
Department of Anaesthetics
DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom
+44 (0)1387 246246
paul.jefferson@nhs.net
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
A1
Study information
Scientific title
Acronym
Study hypothesis
A bolus of ketamine and magnesium at induction does not improve postoperative analgesia following elective total abdominal hysterectomy.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Pain relief post hysterectomy
Intervention
Please note that as of 15/07/10 this trial was never started.
Randomised controlled trial of ketamine and magnesium versus placebo at induction of anaesthesia.
Intervention type
Drug
Phase
Not Applicable
Drug names
Ketamine, magnesium
Primary outcome measures
To determine if the intervention can reduce the use of morphine postoperatively.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/09/2005
Overall trial end date
30/08/2007
Reason abandoned
Eligibility
Participant inclusion criteria
Adult patients with benign disease, scheduled for hysterectomy and able to give informed consent.
Participant type
Patient
Age group
Adult
Gender
Female
Target number of participants
90
Participant exclusion criteria
1. Midline abdominal incision
2. American Society of Anesthesiologists (ASA) >3
3. Age >75 years
4. Long-term use of opioid mediation
5. History of chronic pain syndromes
6. Patients taking antipsychotic medication
7. Major renal or hepatic dsyfunction
8. Neuromuscular disease
9. Surgery - midline incision
Recruitment start date
01/09/2005
Recruitment end date
30/08/2007
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Department of Anaesthetics
Dumfries
DG1 4AP
United Kingdom
Sponsor information
Organisation
NHS Dumfries and Galloway (UK)
Sponsor details
RDSU
DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom
+44 (0)1387 241113
j.lawrence@dgri.scot.nhs.uk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
NHS Dumfries and Galloway (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary