Does a bolus of ketamine and magnesium at induction improve postoperative analgesia following elective total abdominal hysterectomy?
| ISRCTN | ISRCTN22361928 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN22361928 |
| Protocol serial number | A1 |
| Sponsor | NHS Dumfries and Galloway (UK) |
| Funder | NHS Dumfries and Galloway (UK) |
- Submission date
- 08/09/2005
- Registration date
- 31/10/2005
- Last edited
- 15/07/2010
- Recruitment status
- Stopped
- Overall study status
- Stopped
- Condition category
- Signs and Symptoms
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Paul Jefferson
Scientific
Scientific
Department of Anaesthetics
DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom
| Phone | +44 (0)1387 246246 |
|---|---|
| paul.jefferson@nhs.net |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Scientific title | |
| Study objectives | A bolus of ketamine and magnesium at induction does not improve postoperative analgesia following elective total abdominal hysterectomy. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Pain relief post hysterectomy |
| Intervention | Please note that as of 15/07/10 this trial was never started. Randomised controlled trial of ketamine and magnesium versus placebo at induction of anaesthesia. |
| Intervention type | Drug |
| Phase | Not Applicable |
| Drug / device / biological / vaccine name(s) | Ketamine, magnesium |
| Primary outcome measure(s) |
To determine if the intervention can reduce the use of morphine postoperatively. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 30/08/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Female |
| Target sample size at registration | 90 |
| Key inclusion criteria | Adult patients with benign disease, scheduled for hysterectomy and able to give informed consent. |
| Key exclusion criteria | 1. Midline abdominal incision 2. American Society of Anesthesiologists (ASA) >3 3. Age >75 years 4. Long-term use of opioid mediation 5. History of chronic pain syndromes 6. Patients taking antipsychotic medication 7. Major renal or hepatic dsyfunction 8. Neuromuscular disease 9. Surgery - midline incision |
| Date of first enrolment | 01/09/2005 |
| Date of final enrolment | 30/08/2007 |
Locations
Countries of recruitment
- United Kingdom
- Scotland
Study participating centre
Department of Anaesthetics
Dumfries
DG1 4AP
United Kingdom
DG1 4AP
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
