Does a bolus of ketamine and magnesium at induction improve postoperative analgesia following elective total abdominal hysterectomy?

ISRCTN ISRCTN22361928
DOI https://doi.org/10.1186/ISRCTN22361928
Secondary identifying numbers A1
Submission date
08/09/2005
Registration date
31/10/2005
Last edited
15/07/2010
Recruitment status
Stopped
Overall study status
Stopped
Condition category
Signs and Symptoms
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Paul Jefferson
Scientific

Department of Anaesthetics
DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom

Phone +44 (0)1387 246246
Email paul.jefferson@nhs.net

Study information

Study designRandomised controlled trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Hospital
Study typeTreatment
Scientific title
Study objectivesA bolus of ketamine and magnesium at induction does not improve postoperative analgesia following elective total abdominal hysterectomy.
Ethics approval(s)Not provided at time of registration
Health condition(s) or problem(s) studiedPain relief post hysterectomy
InterventionPlease note that as of 15/07/10 this trial was never started.

Randomised controlled trial of ketamine and magnesium versus placebo at induction of anaesthesia.
Intervention typeDrug
Pharmaceutical study type(s)
PhaseNot Applicable
Drug / device / biological / vaccine name(s)Ketamine, magnesium
Primary outcome measureTo determine if the intervention can reduce the use of morphine postoperatively.
Secondary outcome measuresNot provided at time of registration
Overall study start date01/09/2005
Completion date30/08/2007

Eligibility

Participant type(s)Patient
Age groupAdult
SexFemale
Target number of participants90
Key inclusion criteriaAdult patients with benign disease, scheduled for hysterectomy and able to give informed consent.
Key exclusion criteria1. Midline abdominal incision
2. American Society of Anesthesiologists (ASA) >3
3. Age >75 years
4. Long-term use of opioid mediation
5. History of chronic pain syndromes
6. Patients taking antipsychotic medication
7. Major renal or hepatic dsyfunction
8. Neuromuscular disease
9. Surgery - midline incision
Date of first enrolment01/09/2005
Date of final enrolment30/08/2007

Locations

Countries of recruitment

  • Scotland
  • United Kingdom

Study participating centre

Department of Anaesthetics
Dumfries
DG1 4AP
United Kingdom

Sponsor information

NHS Dumfries and Galloway (UK)
Government

RDSU, DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom

Phone +44 (0)1387 241113
Email j.lawrence@dgri.scot.nhs.uk
ROR logo "ROR" https://ror.org/02mcwd725

Funders

Funder type

Government

NHS Dumfries and Galloway (UK)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan