Does a bolus of ketamine and magnesium at induction improve postoperative analgesia following elective total abdominal hysterectomy?
| ISRCTN | ISRCTN22361928 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN22361928 |
| Secondary identifying numbers | A1 |
- Submission date
- 08/09/2005
- Registration date
- 31/10/2005
- Last edited
- 15/07/2010
- Recruitment status
- Stopped
- Overall study status
- Stopped
- Condition category
- Signs and Symptoms
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Paul Jefferson
Scientific
Scientific
Department of Anaesthetics
DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom
| Phone | +44 (0)1387 246246 |
|---|---|
| paul.jefferson@nhs.net |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | |
| Study objectives | A bolus of ketamine and magnesium at induction does not improve postoperative analgesia following elective total abdominal hysterectomy. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Pain relief post hysterectomy |
| Intervention | Please note that as of 15/07/10 this trial was never started. Randomised controlled trial of ketamine and magnesium versus placebo at induction of anaesthesia. |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Applicable |
| Drug / device / biological / vaccine name(s) | Ketamine, magnesium |
| Primary outcome measure | To determine if the intervention can reduce the use of morphine postoperatively. |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/09/2005 |
| Completion date | 30/08/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Female |
| Target number of participants | 90 |
| Key inclusion criteria | Adult patients with benign disease, scheduled for hysterectomy and able to give informed consent. |
| Key exclusion criteria | 1. Midline abdominal incision 2. American Society of Anesthesiologists (ASA) >3 3. Age >75 years 4. Long-term use of opioid mediation 5. History of chronic pain syndromes 6. Patients taking antipsychotic medication 7. Major renal or hepatic dsyfunction 8. Neuromuscular disease 9. Surgery - midline incision |
| Date of first enrolment | 01/09/2005 |
| Date of final enrolment | 30/08/2007 |
Locations
Countries of recruitment
- Scotland
- United Kingdom
Study participating centre
Department of Anaesthetics
Dumfries
DG1 4AP
United Kingdom
DG1 4AP
United Kingdom
Sponsor information
NHS Dumfries and Galloway (UK)
Government
Government
RDSU, DGRI
Bankend Road
Dumfries
DG1 4AP
United Kingdom
| Phone | +44 (0)1387 241113 |
|---|---|
| j.lawrence@dgri.scot.nhs.uk | |
"ROR" |
https://ror.org/02mcwd725 |
Funders
Funder type
Government
NHS Dumfries and Galloway (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
