A randomised double blinded placebo controlled trial of adrenaline in cardiac arrest
| ISRCTN | ISRCTN22893536 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN22893536 |
| Secondary identifying numbers | RA/4/1/0524 |
- Submission date
- 27/03/2003
- Registration date
- 27/03/2003
- Last edited
- 07/10/2021
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Ian Jacobs
Scientific
Scientific
Department of Emergency Medicine
University of Western Australia
35 Stirling Hwy
Nedlands
6009
Australia
| Phone | +61 8 9346 4354 |
|---|---|
| ijacobs@cyllene.uwa.edu.au |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Treatment |
| Scientific title | A randomised double blinded placebo controlled trial of adrenaline in cardiac arrest |
| Study objectives | Intravenous adrenaline administered intravenously does not improve survival following outside of hospital cardiac arrest. |
| Ethics approval(s) | Not provided at time of registration. |
| Health condition(s) or problem(s) studied | Cardiac Arrest |
| Intervention | Patients meeting the above criteria were randomised to receive either placebo administered intravenously (Control arm) or intravenous adrenaline according to standard resuscitation treatment guidelines (Experimental arm). |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | adrenaline |
| Primary outcome measure | Survival to hospital discharge |
| Secondary outcome measures | 1. Return of spontaneous circulation 2. Survival at one year |
| Overall study start date | 01/01/2005 |
| Completion date | 30/06/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 2250 |
| Key inclusion criteria | All patients in cardiac arrest upon arrival of Ambulance Paramedics in whom resuscitation is initiated |
| Key exclusion criteria | 1. Patients under the age of 18 years 2. Patients in which advanced life support was not commenced (i.e. deceased before ambulance arrival) |
| Date of first enrolment | 01/01/2005 |
| Date of final enrolment | 30/06/2007 |
Locations
Countries of recruitment
- Australia
Study participating centre
Department of Emergency Medicine
Nedlands
6009
Australia
6009
Australia
Sponsor information
Western Australian Prehospital Care Research Unit (Australia)
Hospital/treatment centre
Hospital/treatment centre
Department of Emergency Medicine
University of Western Australia
Nedlands
6009
Australia
| Website | http://www.uwa.edu.au/ |
|---|
Funders
Funder type
Research council
National Health and Medical Research Council
Government organisation / National government
Government organisation / National government
- Alternative name(s)
- NHMRC
- Location
- Australia
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | 02/07/2011 | 07/10/2021 | Yes | No |
Editorial Notes
07/10/2021: Publication reference added.
