Thyroid dysfunction in the elderly: quantifying the association between sub-clinical disease and (i) atrial fibrillation (and thus stroke) (ii) depression and (iii) cognitive dysfunction. A community based survey and clinical trial of thyroxine therapy
| ISRCTN | ISRCTN23090699 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN23090699 |
| Secondary identifying numbers | 226/657 |
- Submission date
- 12/09/2002
- Registration date
- 12/09/2002
- Last edited
- 14/09/2007
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nutritional, Metabolic, Endocrine
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Professor James V Parle
Scientific
Scientific
Department of Primary Care and General Practice
University of Birmingham
Edgbaston
B15 2TT
United Kingdom
| Phone | +44 (0)121 414 6420 |
|---|---|
| j.v.parle@bham.ac.uk |
Study information
| Study design | Community based survey and randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | GP practice |
| Study type | Screening |
| Scientific title | |
| Study acronym | BETS (Birmingham Elderly Thyroid Study) |
| Study objectives | Not provided at time of registration |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Thyroid dysfunction |
| Intervention | Intervention: Thyroxine replacement therapy. Dose to be increased by 25 mcg steps during 6 monthly period of monthly monitoring of thyroid function Control: As for intervention group but placebo |
| Intervention type | Other |
| Primary outcome measure | Not provided at time of registration |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/01/2005 |
| Completion date | 01/01/2006 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Not Specified |
| Target number of participants | Not provided at time of registration |
| Key inclusion criteria | Phase 1: Aged 65+ Phase 2a: Patients identified in Phase 1 to be suffering from sub-clinical hyperthyroidism Phase 2b: Patients identified in Phase 1 to be suffering from sub-clinical hypothyroidism |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 01/01/2005 |
| Date of final enrolment | 01/01/2006 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Department of Primary Care and General Practice
Edgbaston
B15 2TT
United Kingdom
B15 2TT
United Kingdom
Sponsor information
The Health Foundation (UK)
Charity
Charity
90 Long Acre
London
WC2E 9RA
United Kingdom
| Phone | +44 (0)20 7257 8000 |
|---|---|
| info@health.org.uk | |
| Website | http://www.pppfoundation.org.uk/ |
"ROR" |
https://ror.org/02bzj4420 |
Funders
Funder type
Charity
The Health Foundation (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | Results for community based survey: | 01/12/2006 | Yes | No |
