A comparison of the effects of Lisinopril and Bendrofluazide on cardiac baroreceptor sensitivity and large artery function following recent ischaemic cerebral stroke

ISRCTN	ISRCTN27475248
DOI	https://doi.org/10.1186/ISRCTN27475248
Protocol serial number	N0123138457
Sponsor	Department of Health
Funder	University Hospitals of Leicester NHS Trust (UK)

Submission date: 30/09/2004
Registration date: 30/09/2004
Last edited: 02/05/2018

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Circulatory System

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr David Eveson
Scientific

University Hospitals of Leicester
c/o Research and Development Office
Leicester General Hospital NHS Trust
Leicester
LE1 4PW
United Kingdom

Phone	+44 (0)116 258 4109
Email	david.eveson@uhl-tr.nhs.uk

Study information

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title	A comparison of the effects of Lisinopril and Bendrofluazide on cardiac baroreceptor sensitivity and large artery function following recent ischaemic cerebral stroke
Study objectives	The aim is to investigate the effects on the cardiovascular system of two, commonly-used, blood pressure-lowering treatments following a recent stroke. The objective is to establish the effects of the thiazide diuretic, Bendrofluazide, and the angiotensin Lisinopril
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Stroke
Intervention	Clinical Study - Human Physiology -Inpatient Admission\| - Multicentre Study: National\|NHS Patients\|Study of Non-Therapeutic Procedure
Intervention type	Drug
Phase	Not Specified
Drug / device / biological / vaccine name(s)	Bendrofluazide, lisinopril
Primary outcome measure(s)	Cardiac baroreceptor sensitivity
Key secondary outcome measure(s)	Not provided at time of registration
Completion date	05/05/2004

Eligibility

Participant type(s)	Patient
Age group	Adult
Lower age limit	18 Years
Sex	Not Specified
Key inclusion criteria	1. The onset of first ischaemic stroke between 2 and 8 weeks prior to randomisation. 2. A mean brachial blood pressure (BP) level measured on 2 different occasions a week apart between 140/90 mmHg and 180/110 mmHg. 3. The presence of sinus rhythm. 4. Age >18 years
Key exclusion criteria	Does not match inclusion criteria
Date of first enrolment	27/05/2003
Date of final enrolment	05/05/2004

Locations

Countries of recruitment

United Kingdom
England

Study participating centre

University Hospitals of Leicester

Leicester
LE1 4PW
United Kingdom

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Editorial Notes

02/05/2018: No publications found, verifying study status with principal investigator.
04/03/2016: No publications found, verifying study status with principal investigator.