Contact information
Type
Scientific
Primary contact
Dr David Eveson
ORCID ID
Contact details
University Hospitals of Leicester
c/o Research and Development Office
Leicester General Hospital NHS Trust
Leicester
LE1 4PW
United Kingdom
+44 (0)116 258 4109
david.eveson@uhl-tr.nhs.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0123138457
Study information
Scientific title
A comparison of the effects of Lisinopril and Bendrofluazide on cardiac baroreceptor sensitivity and large artery function following recent ischaemic cerebral stroke
Acronym
Study hypothesis
The aim is to investigate the effects on the cardiovascular system of two, commonly-used, blood pressure-lowering treatments following a recent stroke. The objective is to establish the effects of the thiazide diuretic, Bendrofluazide, and the angiotensin Lisinopril
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Stroke
Intervention
Clinical Study - Human Physiology -Inpatient Admission| - Multicentre Study: National|NHS Patients|Study of Non-Therapeutic Procedure
Intervention type
Drug
Phase
Not Specified
Drug names
Bendrofluazide, lisinopril
Primary outcome measures
Cardiac baroreceptor sensitivity
Secondary outcome measures
Not provided at time of registration
Overall trial start date
27/05/2003
Overall trial end date
05/05/2004
Reason abandoned
Eligibility
Participant inclusion criteria
1. The onset of first ischaemic stroke between 2 and 8 weeks prior to randomisation.
2. A mean brachial blood pressure (BP) level measured on 2 different occasions a week apart between 140/90 mmHg and 180/110 mmHg.
3. The presence of sinus rhythm.
4. Age >18 years
Participant type
Patient
Age group
Adult
Gender
Not Specified
Target number of participants
Not provided at time of registration
Participant exclusion criteria
Does not match inclusion criteria
Recruitment start date
27/05/2003
Recruitment end date
05/05/2004
Locations
Countries of recruitment
United Kingdom
Trial participating centre
University Hospitals of Leicester
Leicester
LE1 4PW
United Kingdom
Sponsor information
Organisation
Department of Health
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Sponsor type
Government
Website
Funders
Funder type
Hospital/treatment centre
Funder name
University Hospitals of Leicester NHS Trust (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary