A comparison of the effects of Lisinopril and Bendrofluazide on cardiac baroreceptor sensitivity and large artery function following recent ischaemic cerebral stroke
| ISRCTN | ISRCTN27475248 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN27475248 |
| Secondary identifying numbers | N0123138457 |
- Submission date
- 30/09/2004
- Registration date
- 30/09/2004
- Last edited
- 02/05/2018
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr David Eveson
Scientific
Scientific
University Hospitals of Leicester
c/o Research and Development Office
Leicester General Hospital NHS Trust
Leicester
LE1 4PW
United Kingdom
| Phone | +44 (0)116 258 4109 |
|---|---|
| david.eveson@uhl-tr.nhs.uk |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Treatment |
| Scientific title | A comparison of the effects of Lisinopril and Bendrofluazide on cardiac baroreceptor sensitivity and large artery function following recent ischaemic cerebral stroke |
| Study objectives | The aim is to investigate the effects on the cardiovascular system of two, commonly-used, blood pressure-lowering treatments following a recent stroke. The objective is to establish the effects of the thiazide diuretic, Bendrofluazide, and the angiotensin Lisinopril |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Stroke |
| Intervention | Clinical Study - Human Physiology -Inpatient Admission| - Multicentre Study: National|NHS Patients|Study of Non-Therapeutic Procedure |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Bendrofluazide, lisinopril |
| Primary outcome measure | Cardiac baroreceptor sensitivity |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 27/05/2003 |
| Completion date | 05/05/2004 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Sex | Not Specified |
| Target number of participants | Not provided at time of registration |
| Key inclusion criteria | 1. The onset of first ischaemic stroke between 2 and 8 weeks prior to randomisation. 2. A mean brachial blood pressure (BP) level measured on 2 different occasions a week apart between 140/90 mmHg and 180/110 mmHg. 3. The presence of sinus rhythm. 4. Age >18 years |
| Key exclusion criteria | Does not match inclusion criteria |
| Date of first enrolment | 27/05/2003 |
| Date of final enrolment | 05/05/2004 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
University Hospitals of Leicester
Leicester
LE1 4PW
United Kingdom
LE1 4PW
United Kingdom
Sponsor information
Department of Health
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
| Website | http://www.dh.gov.uk/Home/fs/en |
|---|
Funders
Funder type
Hospital/treatment centre
University Hospitals of Leicester NHS Trust (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
02/05/2018: No publications found, verifying study status with principal investigator.
04/03/2016: No publications found, verifying study status with principal investigator.
