Condition category
Circulatory System
Date applied
30/09/2004
Date assigned
30/09/2004
Last edited
04/03/2016
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr David Eveson

ORCID ID

Contact details

University Hospitals of Leicester
c/o Research and Development Office
Leicester General Hospital NHS Trust
Leicester
LE1 4PW
United Kingdom
+44 (0)116 258 4109
david.eveson@uhl-tr.nhs.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N0123138457

Study information

Scientific title

A comparison of the effects of Lisinopril and Bendrofluazide on cardiac baroreceptor sensitivity and large artery function following recent ischaemic cerebral stroke

Acronym

Study hypothesis

The aim is to investigate the effects on the cardiovascular system of two, commonly-used, blood pressure-lowering treatments following a recent stroke. The objective is to establish the effects of the thiazide diuretic, Bendrofluazide, and the angiotensin Lisinopril

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Stroke

Intervention

Clinical Study - Human Physiology -Inpatient Admission| - Multicentre Study: National|NHS Patients|Study of Non-Therapeutic Procedure

Intervention type

Drug

Phase

Not Specified

Drug names

Bendrofluazide, lisinopril

Primary outcome measures

Cardiac baroreceptor sensitivity

Secondary outcome measures

Not provided at time of registration

Overall trial start date

27/05/2003

Overall trial end date

05/05/2004

Reason abandoned

Eligibility

Participant inclusion criteria

1. The onset of first ischaemic stroke between 2 and 8 weeks prior to randomisation.
2. A mean brachial blood pressure (BP) level measured on 2 different occasions a week apart between 140/90 mmHg and 180/110 mmHg.
3. The presence of sinus rhythm.
4. Age >18 years

Participant type

Patient

Age group

Adult

Gender

Not Specified

Target number of participants

Not provided at time of registration

Participant exclusion criteria

Does not match inclusion criteria

Recruitment start date

27/05/2003

Recruitment end date

05/05/2004

Locations

Countries of recruitment

United Kingdom

Trial participating centre

University Hospitals of Leicester
Leicester
LE1 4PW
United Kingdom

Sponsor information

Organisation

Department of Health

Sponsor details

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Sponsor type

Government

Website

http://www.dh.gov.uk/Home/fs/en

Funders

Funder type

Hospital/treatment centre

Funder name

University Hospitals of Leicester NHS Trust (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes

04/03/2016: No publications found, verifying study status with principal investigator.