Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Comparative efficacy of Albendazole and Mebendazole against hookworm infection: Randomised, controlled trial in schoolchildren in Khamkeuth district, Bolikhamxay province, Laos
Acronym
AlMebLaos
Study hypothesis
Albendazole (400 mg single dose) is more effective than mebendazole (500 mg single dose) in clearing hookworm infection.
Ethics approval
National Ethics Committee for Health Research, Vientiane, Laos. Date of approval: 01/04/2008 (ref: 170 /NECHR)
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Hookworm infection, and other intestinal helminth infections
Intervention
Mebendazole (500 mg, single dose, oral) vs albendzole (400 mg, single dose, oral) treatment.
Intervention type
Drug
Phase
Not Specified
Drug names
Albendazole and mebendazole
Primary outcome measures
Hookworm parasite clearance (no hookworm egg in four Kato-Katz slides taken on two stool samples) at 21-23 days after treatment
Secondary outcome measures
Reduction of intensity of infection (reduction of mean number of hookworm eggs counted on four Kato-Katz slides taken on two different stool samples) at 21-23 days after treatment
Overall trial start date
28/04/2008
Overall trial end date
30/05/2008
Reason abandoned
Eligibility
Participant inclusion criteria
1. School-child age between 6 and 16 years, both male and female
2. Hookworm infected (at least one of four egg-positive Kato-Katz slide, established on 2 stool samples)
Participant type
Patient
Age group
Child
Gender
Both
Target number of participants
190
Participant exclusion criteria
1. Pregnancy
2. Severe illness
3. Non-consent
Recruitment start date
28/04/2008
Recruitment end date
30/05/2008
Locations
Countries of recruitment
Laos
Trial participating centre
Swiss Tropical Institute
Basel
4002
Switzerland
Sponsor information
Organisation
Swiss National Science Foundation (Switzerland)
Sponsor details
Wildhainweg 3
P.O. Box 8232
Bern
3001
Switzerland
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
Swiss National Science Foundation (Switzerland)
Alternative name(s)
Swiss National Science Foundation, Fonds National Suisse de la Recherche Scientifique, Fondo Nazionale Svizzero per la Ricerca Scientifica, Fonds National Suisse, Fondo Nazionale Svizzero, Schweizerischer Nationalfonds, SNF, SNSF, FNS
Funding Body Type
private sector organisation
Funding Body Subtype
foundation
Location
Switzerland
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
1. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22235353
Publication citations
-
Results
Soukhathammavong PA, Sayasone S, Phongluxa K, Xayaseng V, Utzinger J, Vounatsou P, Hatz C, Akkhavong K, Keiser J, Odermatt P, Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR., PLoS Negl Trop Dis, 2012, 6, 1, e1417, doi: 10.1371/journal.pntd.0001417.