Condition category
Infections and Infestations
Date applied
25/04/2008
Date assigned
09/10/2008
Last edited
02/05/2012
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Peter Odermatt

ORCID ID

Contact details

Swiss Tropical Institute
Department of Public Health and Epidemiology
Socinstrasse 57
Basel
4002
Switzerland

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Comparative efficacy of Albendazole and Mebendazole against hookworm infection: Randomised, controlled trial in schoolchildren in Khamkeuth district, Bolikhamxay province, Laos

Acronym

AlMebLaos

Study hypothesis

Albendazole (400 mg single dose) is more effective than mebendazole (500 mg single dose) in clearing hookworm infection.

Ethics approval

National Ethics Committee for Health Research, Vientiane, Laos. Date of approval: 01/04/2008 (ref: 170 /NECHR)

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet

Condition

Hookworm infection, and other intestinal helminth infections

Intervention

Mebendazole (500 mg, single dose, oral) vs albendzole (400 mg, single dose, oral) treatment.

Intervention type

Drug

Phase

Not Specified

Drug names

Albendazole and mebendazole

Primary outcome measures

Hookworm parasite clearance (no hookworm egg in four Kato-Katz slides taken on two stool samples) at 21-23 days after treatment

Secondary outcome measures

Reduction of intensity of infection (reduction of mean number of hookworm eggs counted on four Kato-Katz slides taken on two different stool samples) at 21-23 days after treatment

Overall trial start date

28/04/2008

Overall trial end date

30/05/2008

Reason abandoned

Eligibility

Participant inclusion criteria

1. School-child age between 6 and 16 years, both male and female
2. Hookworm infected (at least one of four egg-positive Kato-Katz slide, established on 2 stool samples)

Participant type

Patient

Age group

Child

Gender

Both

Target number of participants

190

Participant exclusion criteria

1. Pregnancy
2. Severe illness
3. Non-consent

Recruitment start date

28/04/2008

Recruitment end date

30/05/2008

Locations

Countries of recruitment

Laos

Trial participating centre

Swiss Tropical Institute
Basel
4002
Switzerland

Sponsor information

Organisation

Swiss National Science Foundation (Switzerland)

Sponsor details

Wildhainweg 3
P.O. Box 8232
Bern
3001
Switzerland

Sponsor type

Government

Website

http://www.snf.ch

Funders

Funder type

Government

Funder name

Swiss National Science Foundation (Switzerland)

Alternative name(s)

Swiss National Science Foundation, Fonds National Suisse de la Recherche Scientifique, Fondo Nazionale Svizzero per la Ricerca Scientifica, Fonds National Suisse, Fondo Nazionale Svizzero, Schweizerischer Nationalfonds, SNF

Funding Body Type

private sector organisation

Funding Body Subtype

foundation

Location

Switzerland

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22235353

Publication citations

  1. Results

    Soukhathammavong PA, Sayasone S, Phongluxa K, Xayaseng V, Utzinger J, Vounatsou P, Hatz C, Akkhavong K, Keiser J, Odermatt P, Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR., PLoS Negl Trop Dis, 2012, 6, 1, e1417, doi: 10.1371/journal.pntd.0001417.

Additional files

Editorial Notes