Rescue angioplasty versus conservative treatment or repeat thrombolysis (the REACT trial)

ISRCTN	ISRCTN31931021
DOI	https://doi.org/10.1186/ISRCTN31931021
Secondary identifying numbers	RG/98005

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr AH Gershlick
Scientific

Academic Dept of Cardiology
Clinical Sciences Wing
Glenfield General Hospital
Leicester
LE3 9QP
United Kingdom

Phone	+44 (0)116 256 3038
Email	agershlick@aol.com

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Treatment
Scientific title
Study acronym	REACT
Study objectives	Not provided at time of registration
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Myocardial infarction
Intervention	Patients to be randomised to: 1. Rescue Percutaneous Transluminal Coronary Angioplasty (PTCA) - stent placement or platelet glycoprotein receptor blockers and the use of intra-aortic balloon pulsation will be guided by clinical need 2. Rescue thrombolysis with tissue Plasminogen Activator (tPA), reteplase, tenecteplase 3. Conservative treatment - intravenous (iv) heparin for 24 hours
Intervention type	Other
Primary outcome measure	Not provided at time of registration
Secondary outcome measures	Not provided at time of registration
Overall study start date	01/12/1999
Completion date	01/03/2004
Reason abandoned (if study stopped)	Other ongoing clinical trials, as well as the introduction of the new thrombolytic agent tenecteplase (and the concomitant unlicensed use of low-molecular-weight heparin), limited the number of suitable candidates for participation. Because of declining trial recruitment and a finite funding period, the steering committee terminated enrolment in the trial in March 2004.

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target number of participants	Not provided at time of registration
Key inclusion criteria	1. Patients with acute myocardial infarction presenting within 6 hours who have received aspirin and an accepted thrombolytic drug 2. Aged 21 - 85 years and able to give informed consent 3. Ability to undertake coronary intervention within 12 hours of onset of chest pain 4. All patients to have failed reperfusion 90 minutes from the start of thrombolysis
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/12/1999
Date of final enrolment	01/03/2004

Academic Dept of Cardiology

Leicester
LE3 9QP
United Kingdom

British Heart Foundation (UK)
Charity

14 Fitzhardinge Street
London
W1H 6DH
United Kingdom

Charity

British Heart Foundation (UK) (ref: RG/98005)
Private sector organisation / Trusts, charities, foundations (both public and private)

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	29/12/2005		Yes	No
Results article	results	07/07/2009		Yes	No