Condition category
Circulatory System
Date applied
16/11/2001
Date assigned
16/11/2001
Last edited
15/07/2009
Prospective/Retrospective
Retrospectively registered
Overall trial status
Stopped
Recruitment status
Stopped

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr AH Gershlick

ORCID ID

Contact details

Academic Dept of Cardiology
Clinical Sciences Wing
Glenfield General Hospital
Leicester
LE3 9QP
United Kingdom
+44 (0)116 256 3038
agershlick@aol.com

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

RG/98005

Study information

Scientific title

Acronym

REACT

Study hypothesis

Not provided at time of registration

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Myocardial infarction

Intervention

Patients to be randomised to:
1. Rescue Percutaneous Transluminal Coronary Angioplasty (PTCA) - stent placement or platelet glycoprotein receptor blockers and the use of intra-aortic balloon pulsation will be guided by clinical need
2. Rescue thrombolysis with tissue Plasminogen Activator (tPA), reteplase, tenecteplase
3. Conservative treatment - intravenous (iv) heparin for 24 hours

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Not provided at time of registration

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/12/1999

Overall trial end date

01/03/2004

Reason abandoned

Other ongoing clinical trials, as well as the introduction of the new thrombolytic agent tenecteplase (and the concomitant unlicensed use of low-molecular-weight heparin), limited the number of suitable candidates for participation. Because of declining trial recruitment and a finite funding period, the steering committee terminated enrolment in the trial in March 2004.

Eligibility

Participant inclusion criteria

1. Patients with acute myocardial infarction presenting within 6 hours who have received aspirin and an accepted thrombolytic drug
2. Aged 21 - 85 years and able to give informed consent
3. Ability to undertake coronary intervention within 12 hours of onset of chest pain
4. All patients to have failed reperfusion 90 minutes from the start of thrombolysis

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

Not provided at time of registration

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

01/12/1999

Recruitment end date

01/03/2004

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Academic Dept of Cardiology
Leicester
LE3 9QP
United Kingdom

Sponsor information

Organisation

British Heart Foundation (UK)

Sponsor details

14 Fitzhardinge Street
London
W1H 6DH
United Kingdom
+44 (0)20 7935 0185
research@bhf.org.uk

Sponsor type

Charity

Website

http://www.bhf.org.uk/

Funders

Funder type

Charity

Funder name

British Heart Foundation (UK) (ref: RG/98005)

Alternative name(s)

BHF

Funding Body Type

private sector organisation

Funding Body Subtype

foundation

Location

United Kingdom

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2005 results in http://www.ncbi.nlm.nih.gov/pubmed/16382062
2. 2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19573727

Publication citations

  1. Results

    Gershlick AH, Stephens-Lloyd A, Hughes S, Abrams KR, Stevens SE, Uren NG, de Belder A, Davis J, Pitt M, Banning A, Baumbach A, Shiu MF, Schofield P, Dawkins KD, Henderson RA, Oldroyd KG, Wilcox R, , Rescue angioplasty after failed thrombolytic therapy for acute myocardial infarction., N. Engl. J. Med., 2005, 353, 26, 2758-2768, doi: 10.1056/NEJMoa050849.

  2. Results

    Carver A, Rafelt S, Gershlick AH, Fairbrother KL, Hughes S, Wilcox R, , Longer-term follow-up of patients recruited to the REACT (Rescue Angioplasty Versus Conservative Treatment or Repeat Thrombolysis) trial., J. Am. Coll. Cardiol., 2009, 54, 2, 118-126, doi: 10.1016/j.jacc.2009.03.050.

Additional files

Editorial Notes