Contribution of inflammatory mechanisms to myocardial and vascular injury in coronary reperfusion
| ISRCTN | ISRCTN33236666 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN33236666 |
| Protocol serial number | 4610 |
| Sponsor | Royal Liverpool University Hospital (UK) |
| Funder | British Heart Foundation |
- Submission date
- 07/07/2010
- Registration date
- 07/07/2010
- Last edited
- 12/08/2016
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Billal Patel
Scientific
Scientific
The Cardiothoracic Centre
Thomas Drive
Liverpool
L14 3PE
United Kingdom
Study information
| Primary study design | Observational |
|---|---|
| Study design | Single centre non-randomised observational trial |
| Secondary study design | Cohort study |
| Scientific title | Contribution of inflammatory mechanisms to myocardial and vascular injury in coronary reperfusion |
| Study acronym | CRF & Endothelial Function |
| Study objectives | This is an observational study investigating the role of inflammation in myocardial microvascular injury following coronary angioplasty and stenting. |
| Ethics approval(s) | MREC approved (ref: 05/Q1502/72 |
| Health condition(s) or problem(s) studied | Topic: Cardiovascular; Subtopic: Cardiovascular (all Subtopics), Generic Health Relevance (all Subtopics); Disease: Cardiovascular, Other |
| Intervention | Patients undergo measurement of inflammatory markers pre- and post-angioplasty and measurement of microvascular function pre- and post-PCI. Study entry: registration only |
| Intervention type | Other |
| Primary outcome measure(s) | Degree of change of microvascular function post-PCI |
| Key secondary outcome measure(s) | Not provided at time of registration |
| Completion date | 14/10/2009 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | All |
| Target sample size at registration | 50 |
| Key inclusion criteria | 1. Undergoing single vessel percutaneous coronary intervention (PCI) in left anterior descending (LAD) or circumflex (Cx) artery 2. Without other signficant coronary disease |
| Key exclusion criteria | 1. Recent acute coronary syndrome (ACS) 2. Other inflammatory disease 3. Asthma |
| Date of first enrolment | 01/04/2006 |
| Date of final enrolment | 14/10/2009 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
The Cardiothoracic Centre
Liverpool
L14 3PE
United Kingdom
L14 3PE
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
12/08/2016: No publications found in PubMed, verifying study status with principal investigator.
