Contribution of inflammatory mechanisms to myocardial and vascular injury in coronary reperfusion
| ISRCTN | ISRCTN33236666 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN33236666 |
| Secondary identifying numbers | 4610 |
- Submission date
- 07/07/2010
- Registration date
- 07/07/2010
- Last edited
- 12/08/2016
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Billal Patel
Scientific
Scientific
The Cardiothoracic Centre
Thomas Drive
Liverpool
L14 3PE
United Kingdom
Study information
| Study design | Single centre non-randomised observational trial |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cohort study |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | Contribution of inflammatory mechanisms to myocardial and vascular injury in coronary reperfusion |
| Study acronym | CRF & Endothelial Function |
| Study objectives | This is an observational study investigating the role of inflammation in myocardial microvascular injury following coronary angioplasty and stenting. |
| Ethics approval(s) | MREC approved (ref: 05/Q1502/72 |
| Health condition(s) or problem(s) studied | Topic: Cardiovascular; Subtopic: Cardiovascular (all Subtopics), Generic Health Relevance (all Subtopics); Disease: Cardiovascular, Other |
| Intervention | Patients undergo measurement of inflammatory markers pre- and post-angioplasty and measurement of microvascular function pre- and post-PCI. Study entry: registration only |
| Intervention type | Other |
| Primary outcome measure | Degree of change of microvascular function post-PCI |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/04/2006 |
| Completion date | 14/10/2009 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Not Specified |
| Sex | Both |
| Target number of participants | Planned sample size: 50 |
| Key inclusion criteria | 1. Undergoing single vessel percutaneous coronary intervention (PCI) in left anterior descending (LAD) or circumflex (Cx) artery 2. Without other signficant coronary disease |
| Key exclusion criteria | 1. Recent acute coronary syndrome (ACS) 2. Other inflammatory disease 3. Asthma |
| Date of first enrolment | 01/04/2006 |
| Date of final enrolment | 14/10/2009 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
The Cardiothoracic Centre
Liverpool
L14 3PE
United Kingdom
L14 3PE
United Kingdom
Sponsor information
Royal Liverpool University Hospital (UK)
Hospital/treatment centre
Hospital/treatment centre
Research & Development, 4th Floor
Linda McCartney Centre
Prescot Street
Liverpool
L7 8XP
England
United Kingdom
| Website | http://www.rlbuht.nhs.uk/ |
|---|---|
"ROR" |
https://ror.org/01ycr6b80 |
Funders
Funder type
Charity
British Heart Foundation
Private sector organisation / Trusts, charities, foundations (both public and private)
Private sector organisation / Trusts, charities, foundations (both public and private)
- Alternative name(s)
- the_bhf, The British Heart Foundation, BHF
- Location
- United Kingdom
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Editorial Notes
12/08/2016: No publications found in PubMed, verifying study status with principal investigator.
