Contact information
Type
Scientific
Primary contact
Mr Matthew Costa
ORCID ID
Contact details
Associate Professor Trauma and Orthopaedics Warwick Medical School
Clinical Sciences Research Institute
Clifford Bridge Road
Coventry
CV2 2DX
United Kingdom
+44 (0)2476 968618
Matthew.Costa@warwick.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
Protocol version 2
Study information
Scientific title
The Warwick Arthroplasty Trial: a randomised controlled trial of total hip arthroplasty versus resurfacing hip arthroplasty in the treatment of young patients with arthritis of the hip joint
Acronym
WAT
Study hypothesis
There is no difference in hip function in patients with severe arthritis of the hip joint who have undergone a total hip arthroplasty or a resurfacing arthroplasty at one year post-operation.
Ethics approval
Approval received from the Coventry Research Ethics Committee on the 9th May 2007 (ref: 07/Q2802/26).
Study design
Randomised single blind controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Osteoarthritis of the hip joint
Intervention
1. Patients in the Total Hip Arthroplasty group will have the head of their femur removed and replaced with a prosthetic component fixed inside the femoral shaft
2. Patients in the Hip Resurfacing Arthroplasty group will have a resurfacing cap placed upon their existing femoral head
Both groups will have a new acetabular (socket) component. The details of both operative procedures will be left to the discretion of the surgeon to increase generalisabilty of the result. All patients will receive standardised rehabilitation after the operation. As part of the research patients will be followed-up for one year post-operation.
Joint sponsor of this trial:
University of Warwick (UK)
c/o Donna McIntyre, Grants and Contracts Officer
Research Support Services
University House, Kirby Corner Road
Coventry CV4 8UW
United Kingdom
Tel: +44 (0)2476 522989
Email: D.McIntyre@warwick.ac.uk
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
1. Harris Hip Score, measured at pre-operation and 6, 12, 26 and 52 weeks post-operation
2. Oxford Hip Score, measured at pre-operation and 6, 12, 26 and 52 weeks post-operation
Secondary outcome measures
All secondary outcomes will be measured at pre-operation and 6, 12, 26 and 52 weeks post-operation:
1. Disability Rating Index
2. Physical activity level
3. Complication rate
4. Quality of life
5. Health economic evaluation
Overall trial start date
01/06/2007
Overall trial end date
31/05/2010
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
1. Over the age of 18
2. Able to give informed consent
3. Eligible for hip resurfacing arthroplasty
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
172
Participant exclusion criteria
Patients with a concomitant medical problem that will preclude operation.
Recruitment start date
01/06/2007
Recruitment end date
31/05/2010
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Associate Professor Trauma and Orthopaedics Warwick Medical School
Coventry
CV2 2DX
United Kingdom
Sponsor information
Organisation
University Hospitals Coventry and Warwickshire NHS Trust (UK)
Sponsor details
c/o Ceri Jones
Research and Development Department
Clifford Bridge Road
Coventry
CV2 2DX
United Kingdom
+44 (0)2476 966196
Ceri.jones@UHCW.nhs.uk
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
National Institute of Health Research (UK) - under the Research for Patient Benefit scheme (ref number: PB-PG-0706-10080)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
1. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20074324
2. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22517930
Publication citations
-
Results
Achten J, Parsons NR, Edlin RP, Griffin DR, Costa ML, A randomised controlled trial of total hip arthroplasty versus resurfacing arthroplasty in the treatment of young patients with arthritis of the hip joint., BMC Musculoskelet Disord, 2010, 11, 8, doi: 10.1186/1471-2474-11-8.
-
Results
Costa ML, Achten J, Parsons NR, Edlin RP, Foguet P, Prakash U, Griffin DR, , Total hip arthroplasty versus resurfacing arthroplasty in the treatment of patients with arthritis of the hip joint: single centre, parallel group, assessor blinded, randomised controlled trial., BMJ, 2012, 344, e2147.