Pharmacogenomics of opioids: an investigation of the genetic determinants of variability in analgesic response to opioids
ISRCTN | ISRCTN35444083 |
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DOI | https://doi.org/10.1186/ISRCTN35444083 |
Secondary identifying numbers | N0258123628 |
- Submission date
- 30/09/2004
- Registration date
- 30/09/2004
- Last edited
- 19/10/2016
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Signs and Symptoms
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Julia Riley
Scientific
Scientific
Palliative Care
Royal Marsden NHS Trust
Fulham Road
Chelsea
London
SW3 6JJ
United Kingdom
Phone | +44 (0)20 7352 8171 |
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Julia.Riley@rmh.nhs.uk |
Study information
Study design | Randomised controlled trial |
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Primary study design | Interventional |
Secondary study design | Randomised controlled trial |
Study setting(s) | Hospital |
Study type | Treatment |
Scientific title | Pharmacogenomics of opioids: an investigation of the genetic determinants of variability in analgesic response to opioids |
Study objectives | The primary aim of this research project is to test the hypothesis that inter-subject variability in response to morphine is determined by polymorphisms in the u-opioid receptor gene. |
Ethics approval(s) | Not provided at time of registration |
Health condition(s) or problem(s) studied | Analgesic response to opioids |
Intervention | Randomised, blinded (Phase 2). Each subject will act as their own control. On visit one, subjects will be randomised to receive either intravenous morphine or intravenous saline (placebo). They will then cross-over to receive placebo or morphine respectively at the second visit. |
Intervention type | Other |
Primary outcome measure | Not provided at time of registration |
Secondary outcome measures | Not provided at time of registration |
Overall study start date | 01/10/2003 |
Completion date | 01/10/2005 |
Eligibility
Participant type(s) | Patient |
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Age group | Not Specified |
Sex | Not Specified |
Target number of participants | 100 |
Key inclusion criteria | Total number RMH patients 100 |
Key exclusion criteria | Not provided at time of registration |
Date of first enrolment | 01/10/2003 |
Date of final enrolment | 01/10/2005 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Palliative Care
London
SW3 6JJ
United Kingdom
SW3 6JJ
United Kingdom
Sponsor information
Department of Health
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Website | http://www.dh.gov.uk/Home/fs/en |
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Funders
Funder type
Government
The Royal Marsden NHS Trust
No information available
Results and Publications
Intention to publish date | |
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Individual participant data (IPD) Intention to share | No |
IPD sharing plan summary | Not provided at time of registration |
Publication and dissemination plan | Not provided at time of registration |
IPD sharing plan |
Editorial Notes
19/10/2016: No publications found in PubMed, verifying study status with principal investigator.