Pharmacogenomics of opioids: an investigation of the genetic determinants of variability in analgesic response to opioids

ISRCTN	ISRCTN35444083
DOI	https://doi.org/10.1186/ISRCTN35444083
Secondary identifying numbers	N0258123628

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr Julia Riley
Scientific

Palliative Care
Royal Marsden NHS Trust
Fulham Road
Chelsea
London
SW3 6JJ
United Kingdom

Phone	+44 (0)20 7352 8171
Email	Julia.Riley@rmh.nhs.uk

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Treatment
Scientific title	Pharmacogenomics of opioids: an investigation of the genetic determinants of variability in analgesic response to opioids
Study objectives	The primary aim of this research project is to test the hypothesis that inter-subject variability in response to morphine is determined by polymorphisms in the u-opioid receptor gene.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Analgesic response to opioids
Intervention	Randomised, blinded (Phase 2). Each subject will act as their own control. On visit one, subjects will be randomised to receive either intravenous morphine or intravenous saline (placebo). They will then cross-over to receive placebo or morphine respectively at the second visit.
Intervention type	Other
Primary outcome measure	Not provided at time of registration
Secondary outcome measures	Not provided at time of registration
Overall study start date	01/10/2003
Completion date	01/10/2005

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target number of participants	100
Key inclusion criteria	Total number RMH patients 100
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	01/10/2003
Date of final enrolment	01/10/2005

Palliative Care

London
SW3 6JJ
United Kingdom

Department of Health
Government

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Website	http://www.dh.gov.uk/Home/fs/en

Government

The Royal Marsden NHS Trust

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

19/10/2016: No publications found in PubMed, verifying study status with principal investigator.