Is a four minute wait required between transfer test measurements?

ISRCTN	ISRCTN37360213
DOI	https://doi.org/10.1186/ISRCTN37360213
Secondary identifying numbers	N0226184632

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Mr Nigel Clayton
Scientific

University Hospital of South Manchester NHS Foundation Trust
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
United Kingdom

Phone	+44 0161 291 2406
Email	nigel.clayton@uhsm.nhs.uk

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Treatment
Participant information sheet	Not available in web format, please use the contact details below to request a patient information sheet
Scientific title	Is a four minute wait required between transfer test measurements?
Study objectives	1. Is a four minute wait required between transfer test measurements? 2. Does airflow obstruction influence the results?
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Respiratory: Function tests
Intervention	Prospective review of pulmonary function tests for patients referred to the pulmonary function laboratory. Participants will be randomised into the order of performing the test. This will either be a one minute wait followed by a four minute wait, or a four minute wait followed by a one minute wait.
Intervention type	Other
Primary outcome measure	Whether the timing of subsequent TLco measurements influences the transfer factor measurement.
Secondary outcome measures	Whether the timing of subsequent TLco measurements influences the alveolar volume measurement.
Overall study start date	01/09/2006
Completion date	01/05/2007

Participant type(s)	Healthy volunteer
Age group	Adult
Lower age limit	18 Years
Sex	Not Specified
Target number of participants	25
Key inclusion criteria	25 subjects from each of the following diagnostic groups: a. Healthy volunteers (no lung disease) b. Asthmatics (variable obstructive lung disease) c. COPD (obstructive lung disease) d. Fibrosis (restrictive lung disease) Inclusion criteria: 1. Over 18 years of age 2. Subject must be able to understand and perform lung function test to national guidelines 3. Non or ex-smokers (>6 months) 4. Physician diagnosis of asthma, COPD or lung fibrosis
Key exclusion criteria	1. Haemoptysis of unknown origin 2. Pneumothorax 3. Unstable cardiovascular status (recent MI or PE) 4. Thoracic, abdominal or cerebral aneurysms 5. Recent eye surgery 6. Nausea and vomiting 7. Recent thoracic or abdominal surgical procedures 8. Involved in other studies with licensed drugs or methodology studies within last weeks
Date of first enrolment	01/09/2006
Date of final enrolment	01/05/2007

University Hospital of South Manchester NHS Foundation Trust

Manchester
M23 9LT
United Kingdom

Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Government

The Department of Health, Richmond House, 79 Whitehall
London
SW1A 2NL
United Kingdom

Government

University Hospital of South Manchester NHS Foundation Trust (UK)

No information available

NHS R&D Support Funding

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

09/08/2021: Internal review.