Additional identifiers
EudraCT number
ClinicalTrials.gov number
NCT00003859
Protocol/serial number
CNS9102
Study information
Scientific title
Trial of chemotherapy utilising carboplatin, vincristine, cyclophosphamide and etoposide for the treatment of central nervous system primitive neurectodermal tumours of childhood
Acronym
Study hypothesis
Not provided at time of registration
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Brain and nervous system cancer
Intervention
All patients receive surgery followed by either:
1. Schedule A: Radiotherapy alone
2. Schedule B: Initial chemotherapy (carboplatin, vincristine, cyclophosphamide and etoposide) followed by radiotherapy
Intervention type
Drug
Phase
Not Applicable
Drug names
Carboplatin, vincristine, cyclophosphamide, etoposide
Primary outcome measure
Not provided at time of registration
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/01/1998
Overall trial end date
28/01/2000
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
1. Aged 3 to 16 years
2. Survival period of at least 1 week following surgery
3. Post-operative Computed Tomography (CT) scan and myelogram
4. No concomitant haematological disorder
5. No previous history of malignant disease
Participant type
Patient
Age group
Child
Gender
Both
Target number of participants
Not provided at time of registration
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/01/1998
Recruitment end date
28/01/2000
Locations
Countries of recruitment
United Kingdom
Trial participating centre
MRC Clinical Trials Unit
London
NW1 2DA
United Kingdom
Sponsor information
Organisation
Cancer Research UK (CRUK) (UK)
Sponsor details
PO Box 123
Lincoln's Inn Fields
London
WC2A 3PX
United Kingdom
+44 (0)207 317 5186
kate.law@cancer.org.uk
Sponsor type
Charity
Website
Funders
Funder type
Charity
Funder name
Cancer Research UK
Alternative name(s)
CRUK
Funding Body Type
private sector organisation
Funding Body Subtype
Other non-profit organizations
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
1. 2003 results in https://www.ncbi.nlm.nih.gov/pubmed/12697884 (added 23/01/2019)
2. 2004 radiotherapy duration results in https://www.ncbi.nlm.nih.gov/pubmed/15001263 (added 23/01/2019)
3. 2004 patient stratification results in https://www.ncbi.nlm.nih.gov/pubmed/15328187
4. 2007 follow-up results in https://www.ncbi.nlm.nih.gov/pubmed/17878477
5. 2009 results for supratentorial primitive neuro-ectodermal tumours (SPNET) subset in https://www.ncbi.nlm.nih.gov/pubmed/19328574