Condition category
Circulatory System
Date applied
06/04/2000
Date assigned
06/04/2000
Last edited
14/01/2013
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Mr RAP Scott

ORCID ID

Contact details

Scott Research Unit
CMEC
St Richard's Hospital
Spitalfield Lane
Chichester
PO19 4SE
United Kingdom

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

G9533930

Study information

Scientific title

Acronym

MASS

Study hypothesis

To assess the effect of ultrasound screening for abdominal aortic aneurysm (AAA) on mortality from ruptured AAA.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Screening

Patient information sheet

Condition

Cardiovascular

Intervention

Ultrasound screening/control

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

1. Mortality for ruptured AAA as detected through the ONS and overall mortality
2. Cost effectiveness of screening for AAA and its effect on quality of life

Secondary outcome measures

Not provided at time of registration

Overall trial start date

17/02/1997

Overall trial end date

16/02/2007

Reason abandoned

Eligibility

Participant inclusion criteria

Men aged 65-74 years on GP lists

Participant type

Patient

Age group

Senior

Gender

Male

Target number of participants

66,000

Participant exclusion criteria

1. Died before randomisation
2. Incorrect patient demographics

Recruitment start date

17/02/1997

Recruitment end date

16/02/2007

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Scott Research Unit
Chichester
PO19 4SE
United Kingdom

Sponsor information

Organisation

Medical Research Council (MRC) (UK)

Sponsor details

20 Park Crescent
London
W1B 1AL
United Kingdom
+44 20 7636 5422
clinical.trial@headoffice.mrc.ac.uk

Sponsor type

Research council

Website

http://www.mrc.ac.uk

Funders

Funder type

Research council

Funder name

Medical Research Council (MRC) (UK)

Alternative name(s)

MRC

Funding Body Type

private sector organisation

Funding Body Subtype

other non-profit

Location

United Kingdom

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2007 results in http://www.ncbi.nlm.nih.gov/pubmed/17502630
2. 2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19553269
3. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/23034729

Publication citations

  1. Results

    Kim LG, P Scott RA, Ashton HA, Thompson SG, , A sustained mortality benefit from screening for abdominal aortic aneurysm., Ann. Intern. Med., 2007, 146, 10, 699-706.

  2. Results

    Thompson SG, Ashton HA, Gao L, Scott RA, , Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study., BMJ, 2009, 338, b2307.

  3. Results

    Thompson SG, Ashton HA, Gao L, Buxton MJ, Scott RA, , Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening., Br J Surg, 2012, 99, 12, 1649-1656, doi: 10.1002/bjs.8897.

Additional files

Editorial Notes