Pre- versus post-dilution haemofiltration: a prospective randomised cross-over study

ISRCTN	ISRCTN38768865
DOI	https://doi.org/10.1186/ISRCTN38768865
Secondary identifying numbers	N/A

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Mrs Anne-Cornelie de Pont
Scientific

Academic Medical Center
Meibergdreef 9
Amsterdam
1105 AZ
Netherlands

Phone	+31 (0)20 5669111 tracer 59229
Email	a.c.depont@amc.uva.nl

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Not specified
Study type	Treatment
Scientific title
Study acronym	PREPOST
Study objectives	Predilution prolongs extracorporeal circuit survival time during continuous venovenous hemofiltration, due to a decrease in platelet activation and thrombin generation.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Acute renal failure
Intervention	Continuous venovenous haemofiltration, predilution versus postdilution
Intervention type	Other
Primary outcome measure	Extracorporeal circuit survival time
Secondary outcome measures	Platelet activation, thrombin generation, urea clearance
Overall study start date	01/12/2000
Completion date	01/01/2002

Participant type(s)	Patient
Age group	Adult
Sex	Both
Target number of participants	7
Key inclusion criteria	Eight critically ill patients with an indication for renal replacement therapy
Key exclusion criteria	Recent bleeding, treatment with aspirin within one week before inclusion or with therapeutic doses of unfractionated or low molecular weight heparin within 12 hours before inclusion or results of routine coagulation tests such as protrombin time (PT) and activated partial thromboplastin time (APTT) exceeding twice the upper limit of normal
Date of first enrolment	01/12/2000
Date of final enrolment	01/01/2002

Academic Medical Center

Amsterdam
1105 AZ
Netherlands

Academic Medical Centre (Netherlands)
Hospital/treatment centre

Prof. dr. M.B. Vroom
Academic Medical Centre
Meibergdreef 9
Amsterdam
1105 AZ
Netherlands

Hospital/treatment centre

Internally funded (Netherlands)

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan