Contact information
Type
Scientific
Primary contact
Mrs Anne-Cornelie de Pont
ORCID ID
Contact details
Academic Medical Center
Meibergdreef 9
Amsterdam
1105 AZ
Netherlands
+31 (0)20 5669111 tracer 59229
a.c.depont@amc.uva.nl
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
PREPOST
Study hypothesis
Predilution prolongs extracorporeal circuit survival time during continuous venovenous hemofiltration, due to a decrease in platelet activation and thrombin generation.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Acute renal failure
Intervention
Continuous venovenous haemofiltration, predilution versus postdilution
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Extracorporeal circuit survival time
Secondary outcome measures
Platelet activation, thrombin generation, urea clearance
Overall trial start date
01/12/2000
Overall trial end date
01/01/2002
Reason abandoned
Eligibility
Participant inclusion criteria
Eight critically ill patients with an indication for renal replacement therapy
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
7
Participant exclusion criteria
Recent bleeding, treatment with aspirin within one week before inclusion or with therapeutic doses of unfractionated or low molecular weight heparin within 12 hours before inclusion or results of routine coagulation tests such as protrombin time (PT) and activated partial thromboplastin time (APTT) exceeding twice the upper limit of normal
Recruitment start date
01/12/2000
Recruitment end date
01/01/2002
Locations
Countries of recruitment
Netherlands
Trial participating centre
Academic Medical Center
Amsterdam
1105 AZ
Netherlands
Sponsor information
Organisation
Academic Medical Centre (Netherlands)
Sponsor details
Prof. dr. M.B. Vroom
Academic Medical Centre
Meibergdreef 9
Amsterdam
1105 AZ
Netherlands
+31 (0)20 5669111 tracer 59155
m.b.vroom@amc.uva.nl
Sponsor type
Hospital/treatment centre
Website
Funders
Funder type
Hospital/treatment centre
Funder name
Internally funded (Netherlands)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary