Condition category
Urological and Genital Diseases
Date applied
05/07/2005
Date assigned
06/07/2005
Last edited
14/09/2009
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Mrs Anne-Cornelie de Pont

ORCID ID

Contact details

Academic Medical Center
Meibergdreef 9
Amsterdam
1105 AZ
Netherlands
+31 (0)20 5669111 tracer 59229
a.c.depont@amc.uva.nl

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

PREPOST

Study hypothesis

Predilution prolongs extracorporeal circuit survival time during continuous venovenous hemofiltration, due to a decrease in platelet activation and thrombin generation.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Acute renal failure

Intervention

Continuous venovenous haemofiltration, predilution versus postdilution

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Extracorporeal circuit survival time

Secondary outcome measures

Platelet activation, thrombin generation, urea clearance

Overall trial start date

01/12/2000

Overall trial end date

01/01/2002

Reason abandoned

Eligibility

Participant inclusion criteria

Eight critically ill patients with an indication for renal replacement therapy

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

7

Participant exclusion criteria

Recent bleeding, treatment with aspirin within one week before inclusion or with therapeutic doses of unfractionated or low molecular weight heparin within 12 hours before inclusion or results of routine coagulation tests such as protrombin time (PT) and activated partial thromboplastin time (APTT) exceeding twice the upper limit of normal

Recruitment start date

01/12/2000

Recruitment end date

01/01/2002

Locations

Countries of recruitment

Netherlands

Trial participating centre

Academic Medical Center
Amsterdam
1105 AZ
Netherlands

Sponsor information

Organisation

Academic Medical Centre (Netherlands)

Sponsor details

Prof. dr. M.B. Vroom
Academic Medical Centre
Meibergdreef 9
Amsterdam
1105 AZ
Netherlands
+31 (0)20 5669111 tracer 59155
m.b.vroom@amc.uva.nl

Sponsor type

Hospital/treatment centre

Website

http://www.amc.uva.nl

Funders

Funder type

Hospital/treatment centre

Funder name

Internally funded (Netherlands)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

Publication citations

Additional files

Editorial Notes