Can insecticide treated window curtains in the household control dengue vectors in the community?
| ISRCTN | ISRCTN39952287 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN39952287 |
| Secondary identifying numbers | N/A |
- Submission date
- 17/03/2010
- Registration date
- 25/03/2010
- Last edited
- 19/02/2020
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Infections and Infestations
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Philip McCall
Scientific
Scientific
Liverpool School of Tropical Medicine
Liverpool
L3 5QA
United Kingdom
Study information
| Study design | Cluster randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Other |
| Study type | Prevention |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | A cluster randomised controlled trial of household-based insecticide treated window curtains for control of the dengue vector Aedes aegypti in the community |
| Study acronym | DENCO Thailand |
| Study objectives | We investigated whether window curtains made of long-lasting insecticide-treated netting and deployed in outer windows of houses could reduce populations of Aedes aegypti, the mosquito vector of dengue, to levels that might lead to reductions in dengue virus transmission in treated communities. |
| Ethics approval(s) | 1. UK: Research Ethics Committee of the Liverpool School of Tropical Medicine approved on the 2nd February 2006 (ref: 06/12) 2. Thailand: Ethics Committee of the Faculty of Tropical Medicine, Mahidol University, Bangkok, approved on the 1st December 2006 (ref: MUTM 2006-056) |
| Health condition(s) or problem(s) studied | Dengue (including Dengue Haemorrhagic Fever [DHF] and Dengue Shock Syndrome [DSS]) |
| Intervention | Curtains made from deltamethrin-coated polyester netting (Long Lasting Impregnated netting; PermaNet® Vestergaard-Frandsen, Lausanne, Switzerland), hung in outer windows regardless of the presence or absence of other window coverings (World Health Organization Pesticide Evaluation Scheme [WHOPES], approved material for indoor use). Control households received no treatment. Following introduction of Insecticide-Treated Materials (ITMs), the total duration of both intervention and follow-up was 12 months. |
| Intervention type | Other |
| Primary outcome measure | Standard larval indices for the Aedes aegypti mosquito: 1. Breteau index: number of containers with immature stages per 100 houses 2. House index: number of houses containing immature stages per 100 houses 3. Container index: number of containers with immature stages per 100 containers with water 4. Pupal surveys were also undertaken to calculate the number of pupae per person index (number of pupae collected/human population in a sector) Follow up surveys were made to all houses at 3, 6, 9 and 12 months post-intervention. Analyses to measure impact of the intervention on dengue vector populations will be undertaken according to intention to treat and per protocol (based on coverage levels recorded in follow-up surveys). |
| Secondary outcome measures | Interviews used to determine: 1. Household characteristics 2. Previous vector control intervention 3. Better understanding of the local population's knowledge, attitudes and practice about previous methods of dengue prevention and control, and about ITMs for the same purpose 4. Insecticide-susceptibility assays undertaken before and after intervention Each house was also georeferenced with a handheld global positioning system receiver to permit subsequent overspill effects between adjacent treated and control clusters to be quantified. |
| Overall study start date | 01/03/2008 |
| Completion date | 30/04/2009 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Other |
| Sex | Both |
| Target number of participants | 2000 households |
| Total final enrolment | 2037 |
| Key inclusion criteria | All occupied households |
| Key exclusion criteria | 1. Business-only premises 2. Multi-storey buildings |
| Date of first enrolment | 01/03/2008 |
| Date of final enrolment | 30/04/2009 |
Locations
Countries of recruitment
- England
- Thailand
- United Kingdom
Study participating centre
Liverpool School of Tropical Medicine
Liverpool
L3 5QA
United Kingdom
L3 5QA
United Kingdom
Sponsor information
Liverpool School of Tropical Medicine (UK)
Research organisation
Research organisation
Pembroke Place
Liverpool
L19 0NB
United Kingdom
| Website | http://www.lstmliverpool.ac.uk/index.htm |
|---|---|
"ROR" |
https://ror.org/03svjbs84 |
Funders
Funder type
Government
European Union (EU) (Belgium) - Sixth Framework Programme (FP6): INCO-DEV-2 (ref: PL 517708)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/02/2013 | 19/02/2020 | Yes | No |
Editorial Notes
19/02/2020: The following changes have been made:
1. Publication reference added.
2. The final enrolment number has been added from the reference.
