Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
The WEAN Study
Study hypothesis
The primary objective of this multicentre pilot study is to compare automatic and protocolised weaning and to evaluate compliance with the proposed weaning and sedation protocols
Ethics approval
Not provided at time of registration
Study design
Multicentre randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Weaning intubated adults from invasive mechanical ventilation
Intervention
Automatic (computer-driven) weaning versus protocolized weaning
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
Compliance with the weaning and sedation protocols
Secondary outcome measures
1. Acceptance of the weaning and sedation protocols
2. Weaning and Intensive Care Unit (ICU) related-complications
3. Time to successful completion of a Single Breath Test (SBT) and extubation
Overall trial start date
30/05/2006
Overall trial end date
01/06/2006
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Patients who are invasively ventilated for at least 24 hours
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
90
Participant exclusion criteria
1. Age < 16 years
2. Tracheotomy
3. Pregnancy
4. Do not intubate (DNI) or do not resuscitate (DNR) patients
5. Planned extubation on the day of study inclusion
6. Planned surgery or procedures within 48 hours of randomization
Recruitment start date
30/05/2006
Recruitment end date
01/06/2006
Locations
Countries of recruitment
Canada
Trial participating centre
St Michael's Hospital
Toronto
M5B 1W8
Canada
Funders
Funder type
Charity
Funder name
Physician Services Incorporated (Canada)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
Draeger Canada (in kind)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
1. 2009 protocol in http://www.ncbi.nlm.nih.gov/pubmed/19732444
2. 2013 results in http://www.ncbi.nlm.nih.gov/pubmed/23525929
Publication citations
-
Protocol
Burns KE, Meade MO, Lessard MR, Keenan SP, Lellouche F, Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial., Trials, 2009, 10, 81, doi: 10.1186/1745-6215-10-81.
-
Results
Burns KE, Meade MO, Lessard MR, Hand L, Zhou Q, Keenan SP, Lellouche F, Wean earlier and automatically with new technology (the WEAN study). A multicenter, pilot randomized controlled trial., Am. J. Respir. Crit. Care Med., 2013, 187, 11, 1203-1211, doi: 10.1164/rccm.201206-1026OC.