Contact information
Type
Scientific
Primary contact
Ms Nicola Turner
ORCID ID
Contact details
Research Office
Leicester General Hospital
Gwendolen Road
Leicester
LE5 4PW
United Kingdom
+44 (0)116 258 4750/6318
nicola.turner@uhl-tr.nhs.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0123090782
Study information
Scientific title
Non-cardiac chest pain: a randomised controlled trial of the effects of antidepressant and acid suppression treatment
Acronym
Study hypothesis
1. To investigate the efficacy of an antidepressant drug compared to acid blockade and placebo for symptomatic relief in non-cardiac chest pain
2. To collect data in an attempt to identify factors predicting response or non-response of these patients to this treatment
3. To develop treatment strategies for this difficult group of patients
4. To correlate effects of treatment with change pain perception and in psychiatric assessment
5. To investigate the effect of treatment on quality of life
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Non-cardiac chest pain
Intervention
Antidepressant drug compared to acid blockade and placebo
Intervention type
Drug
Phase
Not Applicable
Drug names
Antidepressant drug, acid blockade
Primary outcome measures
Not provided at time of registration
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/10/2000
Overall trial end date
31/08/2003
Reason abandoned
Eligibility
Participant inclusion criteria
Patients with non-cardiac chest pain
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
Not provided at time of registration
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/10/2000
Recruitment end date
31/08/2003
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Research Office
Leicester
LE5 4PW
United Kingdom
Sponsor information
Organisation
Department of Health
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Sponsor type
Government
Website
Funders
Funder type
Government
Funder name
University Hospitals of Leicester NHS Trust (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary