Transcranial magnetic stimulation (TMS) in the treatment of depression

ISRCTN	ISRCTN53104648
DOI	https://doi.org/10.1186/ISRCTN53104648
Secondary identifying numbers	N0156116088

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr Joe Johnson
Scientific

Newsham Ward
Broadoak Unit
Broadgreen Hospital
Thomas Drive
Liverpool
L14 3PJ
United Kingdom

Phone	+44 (0) 151 250 5075

Study design	Randomised double-blind placebo-controlled crossover study
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Treatment
Scientific title
Study objectives	It is hypothesised that bilateral transcranial magnetic stimulation (TMS) produces a more rapid symptom response than unilateral TMS in the treatment of major depression.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Mental and Behavioural Disorders: Depression
Intervention	Unilateral rTMS versus bilateral TMS versus sham TMS. The study will be done in two phases. Phase 1 will be done as a pilot study aimed at generating a power calculation to determine the size of the subsequent trial (Phase 2).
Intervention type	Other
Primary outcome measure	It is hoped that the outcome of this project will be improvements in symptom rating scales in depression using the Hamilton Rating Scale and the Beck Depression Inventory
Secondary outcome measures	Not provided at time of registration
Overall study start date	22/07/2002
Completion date	22/07/2004

Participant type(s)	Patient
Age group	Adult
Sex	Not Specified
Target number of participants	Not provided at time of registration
Key inclusion criteria	Suitable subjects will be recruited from the outpatient clinics and inpatient units within Mersey Care NHS Trust in Liverpool, who have been diagnosed as having depression using the Hamilton Depression Rating Scale and Beck Depression Inventory, and are between the ages of 16 to 65 years.
Key exclusion criteria	Not provided at time of registration
Date of first enrolment	22/07/2002
Date of final enrolment	22/07/2004

Newsham Ward

Liverpool
L14 3PJ
United Kingdom

Department of Health (UK)
Government

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Website	http://www.doh.gov.uk

Government

Mersey Care NHS Trust (UK)

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan