Condition category
Not Applicable
Date applied
20/09/2005
Date assigned
28/09/2005
Last edited
10/09/2009
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof Johan L. Severens

ORCID ID

Contact details

Department of Health Organisation
Policy and Economics
P.O. Box 616
Maastricht
6200 MD
Netherlands

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N/A

Study information

Scientific title

Acronym

Study hypothesis

Two hypotheses:
1. Dissemination of locally and multidisciplinairy developed guidelines can lead to a modest but relevant change of volumes of prescriptions in the desired direction
2. What is the additional effect on change of volumes of prescriptions because of involving the target group in the preparation and development of the guidelines

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Not Specified

Patient information sheet

Condition

Improving rational prescribing behaviour among GPs in the Netherlands

Intervention

The randomised intervention concerns the intensified involvement of GPs in the development procedure of a set of prescription guidelines. A randomised subgroup of GPs were invited for a more intense role and received conceptual guidelines to comment on them. The other GPs only received the final version of the prescription guidelines. The second design of our study, the quasi experiment, concerns the dissemination of locally and multidisciplinary guidelines in the south of the Netherlands, controlled by a comparable region elsewhere in the Netherlands. The guidelines contained 14 recommendations on antibiotics, asthma/COPD drugs and cholesterol drugs.

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Prescription data, gathered retrospectively per GP per month during the period 2001-2004. Expected directions of change have been defined based on the detailed recommendations contained in the guidelines, in combination with estimates based on the expertise of the initially involved key regional representatives.

Secondary outcome measures

Drug volumes and pre/post changes between groups on short-term and long term (one and two years after).

Overall trial start date

01/02/2001

Overall trial end date

01/02/2004

Reason abandoned

Eligibility

Participant inclusion criteria

Completeness of the GPs’ data (no missing data per GP for more than one year) and at least 500 patients in the GPs’ practice

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

All GPs in the region Maastricht (n = 53)

Participant exclusion criteria

GPs outside the region

Recruitment start date

01/02/2001

Recruitment end date

01/02/2004

Locations

Countries of recruitment

Netherlands

Trial participating centre

Department of Health Organisation, Policy and Economics
Maastricht
6200 MD
Netherlands

Sponsor information

Organisation

Care and Public Health Research Institute (CAPHRI) (Netherlands)

Sponsor details

P.O. Box 616
Maastricht
6200 MD
Netherlands

Sponsor type

Research organisation

Website

http://www.caphri.unimaas.nl

Funders

Funder type

Industry

Funder name

The two local insurance companies (VGZ and CZ) provided funding sources for this study (Netherlands).

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2006 results in http://www.ncbi.nlm.nih.gov/pubmed/17081285

Publication citations

  1. Results

    Martens JD, Winkens RA, van der Weijden T, de Bruyn D, Severens JL, Does a joint development and dissemination of multidisciplinary guidelines improve prescribing behaviour: a pre/post study with concurrent control group and a randomised trial., BMC Health Serv Res, 2006, 6, 145, doi: 10.1186/1472-6963-6-145.

Additional files

Editorial Notes