Remote ischaemic preconditioning in patients undergoing liver surgery

ISRCTN	ISRCTN54561358
DOI	https://doi.org/10.1186/ISRCTN54561358
Secondary identifying numbers	N0256119281

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Prof Brian R Davidson
Scientific

University Department of Surgery
Royal Free Hampstead NHS Trust
Pond Street
Hampstead
London
NW3 2QG
United Kingdom

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Other
Participant information sheet	Not available in web format, please use the contact details below to request a patient information sheet
Scientific title	Remote ischaemic preconditioning in patients undergoing liver surgery
Study objectives	To study the effects of remote ischaemic preconditioning on liver functions following liver resection or transplantation. To determine whether a brief period of leg ischaemia will reduce ischaemia reperfusion (IR) injury to the liver during liver surgery for liver cancers and liver transplantation. On 13/10/2014 the anticipated end date was changed from 30/06/2004 to 01/09/2015.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Surgery: Liver
Intervention	Blind randomised controlled study
Intervention type	Procedure/Surgery
Primary outcome measure	Does IPC reduce free radical generation and prevent activation of neutrophils observed during IR?
Secondary outcome measures	Not provided at time of registration
Overall study start date	20/12/2002
Completion date	01/09/2015

Participant type(s)	Patient
Age group	Other
Sex	Both
Target number of participants	48
Key inclusion criteria	48 patients with 24 controls for each category (48 controls in all)
Key exclusion criteria	Does not match inclusion criteria
Date of first enrolment	20/12/2002
Date of final enrolment	01/09/2015

University Department of Surgery

London
NW3 2QG
United Kingdom

Department of Health (UK)
Government

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Website	http://www.doh.gov.uk

Hospital/treatment centre

The Royal Free Hampstead NHS Trust (UK)

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/09/2017		Yes	No

07/02/2019: Publication reference added.