Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0256119281
Study information
Scientific title
Remote ischaemic preconditioning in patients undergoing liver surgery
Acronym
Study hypothesis
To study the effects of remote ischaemic preconditioning on liver functions following liver resection or transplantation. To determine whether a brief period of leg ischaemia will reduce ischaemia reperfusion (IR) injury to the liver during liver surgery for liver cancers and liver transplantation.
On 13/10/2014 the anticipated end date was changed from 30/06/2004 to 01/09/2015.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Other
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Surgery: Liver
Intervention
Blind randomised controlled study
Intervention type
Procedure/Surgery
Phase
Not Applicable
Drug names
Primary outcome measure
Does IPC reduce free radical generation and prevent activation of neutrophils observed during IR?
Secondary outcome measures
Not provided at time of registration
Overall trial start date
20/12/2002
Overall trial end date
01/09/2015
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
48 patients with 24 controls for each category (48 controls in all)
Participant type
Patient
Age group
Other
Gender
Both
Target number of participants
48
Participant exclusion criteria
Does not match inclusion criteria
Recruitment start date
20/12/2002
Recruitment end date
01/09/2015
Locations
Countries of recruitment
United Kingdom
Trial participating centre
University Department of Surgery
London
NW3 2QG
United Kingdom
Sponsor information
Organisation
Department of Health (UK)
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Sponsor type
Government
Website
Funders
Funder type
Hospital/treatment centre
Funder name
The Royal Free Hampstead NHS Trust (UK)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28651898