Remote ischaemic preconditioning in patients undergoing liver surgery
ISRCTN | ISRCTN54561358 |
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DOI | https://doi.org/10.1186/ISRCTN54561358 |
Secondary identifying numbers | N0256119281 |
- Submission date
- 12/09/2003
- Registration date
- 12/09/2003
- Last edited
- 07/02/2019
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Surgery
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof Brian R Davidson
Scientific
Scientific
University Department of Surgery
Royal Free Hampstead NHS Trust
Pond Street
Hampstead
London
NW3 2QG
United Kingdom
Study information
Study design | Randomised controlled trial |
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Primary study design | Interventional |
Secondary study design | Randomised controlled trial |
Study setting(s) | Hospital |
Study type | Other |
Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
Scientific title | Remote ischaemic preconditioning in patients undergoing liver surgery |
Study objectives | To study the effects of remote ischaemic preconditioning on liver functions following liver resection or transplantation. To determine whether a brief period of leg ischaemia will reduce ischaemia reperfusion (IR) injury to the liver during liver surgery for liver cancers and liver transplantation. On 13/10/2014 the anticipated end date was changed from 30/06/2004 to 01/09/2015. |
Ethics approval(s) | Not provided at time of registration |
Health condition(s) or problem(s) studied | Surgery: Liver |
Intervention | Blind randomised controlled study |
Intervention type | Procedure/Surgery |
Primary outcome measure | Does IPC reduce free radical generation and prevent activation of neutrophils observed during IR? |
Secondary outcome measures | Not provided at time of registration |
Overall study start date | 20/12/2002 |
Completion date | 01/09/2015 |
Eligibility
Participant type(s) | Patient |
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Age group | Other |
Sex | Both |
Target number of participants | 48 |
Key inclusion criteria | 48 patients with 24 controls for each category (48 controls in all) |
Key exclusion criteria | Does not match inclusion criteria |
Date of first enrolment | 20/12/2002 |
Date of final enrolment | 01/09/2015 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
University Department of Surgery
London
NW3 2QG
United Kingdom
NW3 2QG
United Kingdom
Sponsor information
Department of Health (UK)
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Website | http://www.doh.gov.uk |
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Funders
Funder type
Hospital/treatment centre
The Royal Free Hampstead NHS Trust (UK)
No information available
Results and Publications
Intention to publish date | |
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Individual participant data (IPD) Intention to share | No |
IPD sharing plan summary | Not provided at time of registration |
Publication and dissemination plan | Not provided at time of registration |
IPD sharing plan |
Study outputs
Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
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Results article | results | 01/09/2017 | Yes | No |
Editorial Notes
07/02/2019: Publication reference added.