Remote ischaemic preconditioning in patients undergoing liver surgery

ISRCTN ISRCTN54561358
DOI https://doi.org/10.1186/ISRCTN54561358
Secondary identifying numbers N0256119281
Submission date
12/09/2003
Registration date
12/09/2003
Last edited
07/02/2019
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Surgery
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Prof Brian R Davidson
Scientific

University Department of Surgery
Royal Free Hampstead NHS Trust
Pond Street
Hampstead
London
NW3 2QG
United Kingdom

Study information

Study designRandomised controlled trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Hospital
Study typeOther
Participant information sheet Not available in web format, please use the contact details below to request a patient information sheet
Scientific titleRemote ischaemic preconditioning in patients undergoing liver surgery
Study objectivesTo study the effects of remote ischaemic preconditioning on liver functions following liver resection or transplantation. To determine whether a brief period of leg ischaemia will reduce ischaemia reperfusion (IR) injury to the liver during liver surgery for liver cancers and liver transplantation.

On 13/10/2014 the anticipated end date was changed from 30/06/2004 to 01/09/2015.
Ethics approval(s)Not provided at time of registration
Health condition(s) or problem(s) studiedSurgery: Liver
InterventionBlind randomised controlled study
Intervention typeProcedure/Surgery
Primary outcome measureDoes IPC reduce free radical generation and prevent activation of neutrophils observed during IR?
Secondary outcome measuresNot provided at time of registration
Overall study start date20/12/2002
Completion date01/09/2015

Eligibility

Participant type(s)Patient
Age groupOther
SexBoth
Target number of participants48
Key inclusion criteria48 patients with 24 controls for each category (48 controls in all)
Key exclusion criteriaDoes not match inclusion criteria
Date of first enrolment20/12/2002
Date of final enrolment01/09/2015

Locations

Countries of recruitment

  • England
  • United Kingdom

Study participating centre

University Department of Surgery
London
NW3 2QG
United Kingdom

Sponsor information

Department of Health (UK)
Government

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Website http://www.doh.gov.uk

Funders

Funder type

Hospital/treatment centre

The Royal Free Hampstead NHS Trust (UK)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan

Study outputs

Output type Details Date created Date added Peer reviewed? Patient-facing?
Results article results 01/09/2017 Yes No

Editorial Notes

07/02/2019: Publication reference added.