Condition category
Surgery
Date applied
12/09/2003
Date assigned
12/09/2003
Last edited
09/09/2009
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Mr Stephen Large

ORCID ID

Contact details

Surgical Unit Top Floor
Papworth Hospital NHS Trust
Papworth Everard
Cambridge
CB3 8RE
United Kingdom

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

N0542115296

Study information

Scientific title

Acronym

Study hypothesis

To determine the most effective anti-platelet agent following coronary artery by pass grafting (CABG).

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Coronary artery bypass grafting (CABG)

Intervention

Patients will be randomised into treatment allocation to receive either 100 mg aspirin, 325 mg aspirin or identically encapsulated 75 mg clopidogrel daily for 5 days.

Intervention type

Procedure/Surgery

Phase

Not Specified

Drug names

Primary outcome measures

Platelet aggregation ratio at 5 days.

Secondary outcome measures

Not provided at time of registration

Overall trial start date

28/08/2002

Overall trial end date

01/06/2004

Reason abandoned

Eligibility

Participant inclusion criteria

72 Patients and 36 controls will be recruited from patients proceeding to coronary artery bypass surgery.

Participant type

Patient

Age group

Not Specified

Gender

Not Specified

Target number of participants

108

Participant exclusion criteria

Does not match inclusion criteria

Recruitment start date

28/08/2002

Recruitment end date

01/06/2004

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Surgical Unit Top Floor
Cambridge
CB3 8RE
United Kingdom

Sponsor information

Organisation

Department of Health (UK)

Sponsor details

Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Sponsor type

Government

Website

http://www.doh.gov.uk

Funders

Funder type

Hospital/treatment centre

Funder name

Cambridge Consortium - Papworth Hospital NHS Trust (UK) - Papworth Hospital Charitable Funds

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2004 results in http://www.ncbi.nlm.nih.gov/pubmed/15354104

Publication citations

  1. Results

    Lim E, Cornelissen J, Routledge T, Kirtland S, Charman SC, Bellm S, Munday H, Khan O, Masood I, Large S, Clopidogrel did not inhibit platelet function early after coronary bypass surgery: A prospective randomized trial., J. Thorac. Cardiovasc. Surg., 2004, 128, 3, 432-435, doi: 10.1016/j.jtcvs.2004.03.007.

Additional files

Editorial Notes