The Hertfordshire Physical Activity Trial

ISRCTN	ISRCTN60986572
DOI	https://doi.org/10.1186/ISRCTN60986572
ClinicalTrials.gov (NCT)	Nil known
Clinical Trials Information System (CTIS)	Nil known
Protocol serial number	Nil known
Sponsor	Medical Research Council Epidemiology Unit (UK)
Funder	Medical Research Council Epidemiology Unit (UK)

Submission date: 31/10/2007
Registration date: 23/01/2008
Last edited: 27/03/2025

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Nutritional, Metabolic, Endocrine

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Contact information

Prof Nick Wareham
Scientific

Medical Research Council Epidemiology Unit
Institute of Metabolic Science
BOX 285
Hills Road
Cambridge
CB2 0QQ
United Kingdom

Study information

Primary study design	Interventional
Study design	Randomised controlled single-centre trial
Secondary study design	Randomised controlled trial
Scientific title	The Hertfordshire Physical Activity Trial
Study objectives	The aim of the study is to determine whether differential responses to a physical activity training programme are seen between individuals with low birth weight compared to individuals with a normal birth weight. More details can be found at: http://www.mrc.ac.uk/ResearchPortfolio/Grant/Record.htm?RecType=Unit&AgreementId=88572&CaseId=21340
Ethics approval(s)	Ethics approval received from the Hertfordshire Local Research Ethics Committee on the 23rd May 2005 (ref: 05/Q0201/23).
Health condition(s) or problem(s) studied	Metabolic risk
Intervention	Aerobic exercise programme versus care as usual. The control group continue with their normal activities. The exercise group take part in a fully supervised 12- week aerobic exercise programme. There are three sessions each week and each one lasts sixty minutes. Contact for queries: Miss Jessica Horton Email: Jessica.Horton@mrc-epid.cam.ac.uk
Intervention type	Other
Primary outcome measure(s)	Clustered Metabolic Risk Score. Study participants return for their second visit thirteen weeks after their baseline visit. The outcomes will be measured at this time.
Key secondary outcome measure(s)	1. Body composition 2. Insulin sensitivity 3. Physical fitness Study participants return for their second visit thirteen weeks after their baseline visit. The outcomes will be measured at this time.
Completion date	01/03/2008

Eligibility

Participant type(s)	Healthy volunteer
Age group	Senior
Sex	All
Target sample size at registration	100
Key inclusion criteria	1. Healthy volunteers from the Hertfordshire Birth Cohort 2. Male and female, born between 1931 - 1939
Key exclusion criteria	1. Diabetes 2. Untreated hypertension 3. Ischaemic heart disease
Date of first enrolment	17/01/2007
Date of final enrolment	01/03/2008

Locations

Countries of recruitment

United Kingdom
England

Study participating centre

Medical Research Council Epidemiology Unit

Cambridge
CB2 0QQ
United Kingdom

Results and Publications

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Study outputs

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/04/2010		Yes	No
Results article		25/03/2025	27/03/2025	Yes	No
Protocol article	protocol	19/06/2009		Yes	No

Editorial Notes

27/03/2025: Publication reference added.