Sevoflurane inhalational introduction in the elderly: a comparison with intravenous induction
| ISRCTN | ISRCTN61123518 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN61123518 |
| Protocol serial number | N0192080350 |
| Sponsor | Department of Health (UK) |
| Funders | Queens Medical Centre, Nottingham University Hospital NHS Trust (UK) - NHS R&D Support Funding, Abbott Laboratories (UK) |
- Submission date
- 12/09/2003
- Registration date
- 12/09/2003
- Last edited
- 11/10/2016
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Surgery
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr MH Nathanson
Scientific
Scientific
Department of Anaethesia
C Floor, University Hospital
Nottingham
NG7 2UH
United Kingdom
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | Sevoflurane inhalational introduction in the elderly: a comparison with intravenous induction |
| Study objectives | The aim of the study is to compare the effects of an inhalational induction of anaesthesia with sevoflurane with an intravenous induction in elderly patients. In particular, we will assess the effects on cardiovascular parameters (heart rate, blood pressure), and cerebral blood flow velocity. We hypothesise that compared with an intravenous induction an inhalational induction will be more stable. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Anaesthesia |
| Intervention | Randomised controlled trial: 1. Inhalational induction of anaesthesia with sevoflurane 2. Intravenous induction of anaesthesia with sevoflurane |
| Intervention type | Drug |
| Phase | Not Applicable |
| Drug / device / biological / vaccine name(s) | Sevoflurane |
| Primary outcome measure(s) |
Change in blood pressure and cerebral flow velocity during induction of anaesthesia compared to baseline values. |
| Key secondary outcome measure(s) |
Not provided at time of registration |
| Completion date | 14/11/2002 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Senior |
| Sex | All |
| Target sample size at registration | 40 |
| Key inclusion criteria | Total number of subjects = 40 |
| Key exclusion criteria | Not provided at time of registration |
| Date of first enrolment | 20/08/2001 |
| Date of final enrolment | 14/11/2002 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
University Hospital
Nottingham
NG7 2UH
United Kingdom
NG7 2UH
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
Editorial Notes
11/10/2016: No publications found, verifying study status with principal investigator.
