Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N0192080350
Study information
Scientific title
Sevoflurane inhalational introduction in the elderly: a comparison with intravenous induction
Acronym
Study hypothesis
The aim of the study is to compare the effects of an inhalational induction of anaesthesia with sevoflurane with an intravenous induction in elderly patients. In particular, we will assess the effects on cardiovascular parameters (heart rate, blood pressure), and cerebral blood flow velocity. We hypothesise that compared with an intravenous induction an inhalational induction will be more stable.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Not available in web format, please use contact details to request a participant information sheet
Condition
Anaesthesia
Intervention
Randomised controlled trial:
1. Inhalational induction of anaesthesia with sevoflurane
2. Intravenous induction of anaesthesia with sevoflurane
Intervention type
Drug
Phase
Not Applicable
Drug names
Sevoflurane
Primary outcome measure
Change in blood pressure and cerebral flow velocity during induction of anaesthesia compared to baseline values.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
20/08/2001
Overall trial end date
14/11/2002
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Total number of subjects = 40
Participant type
Patient
Age group
Senior
Gender
Both
Target number of participants
40
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
20/08/2001
Recruitment end date
14/11/2002
Locations
Countries of recruitment
United Kingdom
Trial participating centre
University Hospital
Nottingham
NG7 2UH
United Kingdom
Sponsor information
Organisation
Department of Health (UK)
Sponsor details
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
Sponsor type
Government
Website
Funders
Funder type
Hospital/treatment centre
Funder name
Queens Medical Centre, Nottingham University Hospital NHS Trust (UK) - NHS R&D Support Funding
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
Abbott Laboratories (UK)
Alternative name(s)
Abbott, Abbott U.S.
Funding Body Type
private sector organisation
Funding Body Subtype
For-profit companies (industry)
Location
United States of America
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list