Treatment of psoriasis by pulsed dye lasers: short-term and long-term (4 years) results

ISRCTN ISRCTN66115464
DOI https://doi.org/10.1186/ISRCTN66115464
Secondary identifying numbers N/A
Submission date
18/06/2008
Registration date
30/09/2008
Last edited
30/09/2008
Recruitment status
No longer recruiting
Overall study status
Completed
Condition category
Skin and Connective Tissue Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Jean Michel Mazer
Scientific

Centre Laser Trevise
49 rue de Trevise
Paris
75009
France

Study information

Study designRandomised controlled trial
Primary study designInterventional
Secondary study designRandomised controlled trial
Study setting(s)Not specified
Study typeTreatment
Scientific title
Study objectivesPrevious studies with pulsed dye lasers showed improvement of chronic plaques of psoriasis and, sometimes, total clearing. This study aims to investigate the efficacy of the pulsed dye laser treatment on psoriasis plaques by comparing the affected areas that have been treated with the laser against the untreated area within an individual.
Ethics approval(s)The study was approved by the local ethics committee (CCPPRB Paris Saint-Louis) on 21st April 2001 (ref: 2001/13)
Health condition(s) or problem(s) studiedPsoriasis
InterventionTwo plaques were investigated in each patient, and for both plaques, 1/4 of the total area was left untreated (control area). The remaining area of both plaques were treated with the pulsed dye laser.

Randomisation: The plaques were divided in four quadrants and, by draw (throwing a four sided dice), one quadrant was chosen as the control area and the other three were treated.
Intervention typeOther
Primary outcome measureClinical score at baseline and 6 weeks after the last and third treatment by pulsed dye laser.
Secondary outcome measuresAdverse effects, followed-up for at least 2 years.
Overall study start date02/09/2002
Completion date02/10/2008

Eligibility

Participant type(s)Patient
Age groupAdult
Lower age limit18 Years
SexBoth
Target number of participants28
Key inclusion criteria1. Both males and females, minimum age = 18, no upper age limit
2. Psoriasis: chronic and untreated plaques
Key exclusion criteria1. Pregnant women
2. Minors
3. Patients who had received local treatment during the last month or oral treatment during the last 6 weeks (cyclosporin, retinoids, methotrexate, corticosteroids)
Date of first enrolment02/09/2002
Date of final enrolment02/10/2008

Locations

Countries of recruitment

  • France

Study participating centre

Centre Laser Trevise
Paris
75009
France

Sponsor information

Saint Louis Hospital (France)
Hospital/treatment centre

c/o Prof L Dubertret
Department of Dermatology
Paris
75010
France

Website http://www.chu-stlouis.fr
ROR logo "ROR" https://ror.org/049am9t04

Funders

Funder type

Hospital/treatment centre

Saint Louis Hospital (France)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to shareNo
IPD sharing plan summaryNot provided at time of registration
Publication and dissemination planNot provided at time of registration
IPD sharing plan