Mirror therapy in patients with complex regional pain syndrome type one of the upper extremity: a randomised clinical trial

ISRCTN	ISRCTN68438240
DOI	https://doi.org/10.1186/ISRCTN68438240
Secondary identifying numbers	N/A

Submission date: 23/02/2007
Registration date: 23/02/2007
Last edited: 08/09/2011

Recruitment status: No longer recruiting
Overall study status: Completed
Condition category: Musculoskeletal Diseases

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Contact information

Dr Ton A R Schreuders
Scientific

Erasmus Medical Centre
Department of Rehabilitation Medicine, Room H014
P.O. Box 2040
Rotterdam
3000 CA
Netherlands

Phone	+31 (0)10 463 2867
Email	a.schreuders@erasmusmc.nl

Study information

Study design	Randomised, active controlled, parallel group, single blinded trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Other
Study type	Treatment
Scientific title
Study objectives	Mirror therapy was introduced by Ramachandran in patient with phantom limb pain and is based on new knowledge about the plasticity of the brain. Recently, studies in patients with Complex Regional Pain Syndrome (CRPS) have suggested that exercising with the painful hand behind a mirror and watching a reflection of the normal hand will give the brain the illusion that the hand is now able to move normally. In these controlled but undersized studies, positive effects were reported on pain, oedema and hand function. In the present single-blind randomised clinical trial, mirror therapy will be presented in three phases: 1. One week Recognition of Hand Laterality using pictures of left and right hands 2. One week of Imagined Hand Movements, and 3. Four weeks of mirror therapy Hypothesis: Mirror therapy in patients with Complex Regional Pain Syndrome type one (CRPS I) has a positive effect on pain, oedema, sensibility, hand function, Activities of Daily Living (ADL) and quality of life compared to standard treatment.
Ethics approval(s)	Ethics approval received from the local medical ethics committee
Health condition(s) or problem(s) studied	Complex regional pain syndrome type 1 (CRPS I)
Intervention	Mirror therapy versus standard treatment: 1. One week recognition of hand laterality using pictures of left and right hands 2. One week of imagined hand movements, and 3. Four weeks of mirror therapy The control group will receive treatment following standard treatment guidelines.
Intervention type	Other
Primary outcome measure	Pain
Secondary outcome measures	1. Hand function 2. ADL 3. Oedema 4. Sensibility 5. Quality of life
Overall study start date	01/12/2005
Completion date	01/12/2007

Eligibility

Participant type(s)	Patient
Age group	Not Specified
Sex	Not Specified
Target number of participants	52
Key inclusion criteria	Modified research diagnostic criteria for CRPS-1 based on Bruehl 1999.
Key exclusion criteria	1. Treatment for CRPS-I in another institution 2. Psychiatric problems 3. Lack of motivation
Date of first enrolment	01/12/2005
Date of final enrolment	01/12/2007

Locations

Countries of recruitment

Netherlands

Study participating centre

Erasmus Medical Centre

Rotterdam
3000 CA
Netherlands

Sponsor information

Erasmus Medical Centre (The Netherlands)
Hospital/treatment centre

P.O. Box 2040
Rotterdam
3000 CA
Netherlands

Website	http://www.erasmusmc.nl/
"ROR"	https://ror.org/018906e22

Funders

Funder type

Hospital/treatment centre

Erasmus Medical Centre (The Netherlands)

No information available

Medical Research Advisory Committee Erasmus (MRACE) (The Netherlands)

No information available

Results and Publications

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan