Contact information
Type
Scientific
Primary contact
Dr Diederik WJ Dippel
ORCID ID
Contact details
Erasmus Medical Centre
PO Box 1738
Rotterdam
3000 DR
Netherlands
+31 (0)10 408 7979
d.dippel@erasmusmc.nl
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
BLOPP
Study hypothesis
The purpose of the study is to assess the effect of an epidural blood on postpunctional headache after a diagnostic lumbar puncture (the formal hypothesis would be that there is no effect on postpunctional headache).
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Post Lumbar Puncture Headache
Intervention
Blood patch versus conservative treatment
Intervention type
Procedure/Surgery
Phase
Not Specified
Drug names
Primary outcome measures
Presence of postpunctional headache at 24 hours after inclusion in the study
Secondary outcome measures
1. Presence of postpunctional headache at 7 days
2. The number of days until headache subsides
Overall trial start date
01/01/2002
Overall trial end date
31/12/2005
Reason abandoned
Eligibility
Participant inclusion criteria
Patients with postpunctional headache after a diagnostic lumbar puncture
Participant type
Patient
Age group
Not Specified
Gender
Not Specified
Target number of participants
40
Participant exclusion criteria
Not provided at time of registration
Recruitment start date
01/01/2002
Recruitment end date
31/12/2005
Locations
Countries of recruitment
Netherlands
Trial participating centre
Erasmus Medical Centre
Rotterdam
3000 DR
Netherlands
Funders
Funder type
Research organisation
Funder name
Netherlands Headache Society (Nederlandse Hoofdpijn Vereniging) (The Netherlands)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
Results in:
1. http://www.ncbi.nlm.nih.gov/pubmed/15998467
2. http://www.ncbi.nlm.nih.gov/pubmed/17635971
Publication citations
-
Oedit R, van Kooten F, Bakker SL, Dippel DW, Efficacy of the epidural blood patch for the treatment of post lumbar puncture headache BLOPP: a randomised, observer-blind, controlled clinical trial [ISRCTN 71598245]., BMC Neurol, 2005, 5, 1, 12, doi: 10.1186/1471-2377-5-12.
-
van Kooten F, Oedit R, Bakker SL, Dippel DW, Epidural blood patch in post dural puncture headache: a randomised, observer-blind, controlled clinical trial., J. Neurol. Neurosurg. Psychiatr., 2008, 79, 5, 553-558, doi: 10.1136/jnnp.2007.122879.