The arcOGEN study: a genome wide association study of osteoarthritis
| ISRCTN | ISRCTN73561469 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN73561469 |
| Secondary identifying numbers | 4628 |
- Submission date
- 23/04/2010
- Registration date
- 27/05/2010
- Last edited
- 22/11/2013
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Musculoskeletal Diseases
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Prof John Loughlin
Scientific
Scientific
The Medical School
Queen Victoria Road
Newcastle
NE1 4LP
United Kingdom
Study information
| Study design | Non-randomised observational trial in primary, secondary and tertiary centres |
|---|---|
| Primary study design | Observational |
| Secondary study design | Multi-centre |
| Study setting(s) | Other |
| Study type | Screening |
| Participant information sheet | Not available in web format, please use the contact details below to request a patient information sheet |
| Scientific title | A non-randomised observational trial in participants with primary osteoarthritis who will be used for mapping osteoarthritis susceptibility genes by genome-wide association scan |
| Study acronym | arcOGEN |
| Study objectives | A collection of participants with primary osteoarthritis who will be used for mapping osteoarthritis susceptibility genes by genome-wide association scan and by other genetic approaches. |
| Ethics approval(s) | Oxfordshire Research Ethics Committee (REC) C approved on the 3rd January 2008 (ref: 07/H0606/150) |
| Health condition(s) or problem(s) studied | Topic: Musculoskeletal; Subtopic: Musculoskeletal (all Subtopics); Disease: Musculoskeletal |
| Intervention | There is no intervention in this trial. Recruited participants have a blood sample taken for a DNA test and a questionnaire will be answered. No treatments are given. |
| Intervention type | Other |
| Primary outcome measure | Questionnaire, completed at time of blood sampling |
| Secondary outcome measures | No secondary outcome measures |
| Overall study start date | 01/03/2008 |
| Completion date | 31/12/2010 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | Planned Sample Size: 8000; UK Sample Size: 8000 |
| Key inclusion criteria | 1. Primary osteoarthritis ascertained by joint replacement of the hip or the knee 2. Male and female, lower age limit of 40 years |
| Key exclusion criteria | Secondary forms of osteoarthritis or non-osteoarthritic diseases that result in joint replacement surgery |
| Date of first enrolment | 01/03/2008 |
| Date of final enrolment | 31/12/2010 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
The Medical School
Newcastle
NE1 4LP
United Kingdom
NE1 4LP
United Kingdom
Sponsor information
Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)
Hospital/treatment centre
Hospital/treatment centre
Wolfson Unit of Clinical Pharmacology
Institute of Cellular Medicine
Framlington Place
Newcastle
NE2 4HH
England
United Kingdom
| Website | http://www.newcastle-hospitals.org.uk/ |
|---|---|
"ROR" |
https://ror.org/05p40t847 |
Funders
Funder type
Charity
Arthritis Research Campaign (ARC) (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/05/2011 | Yes | No | |
| Results article | results | 01/09/2012 | Yes | No |
