Condition category
Musculoskeletal Diseases
Date applied
23/04/2010
Date assigned
27/05/2010
Last edited
22/11/2013
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof John Loughlin

ORCID ID

Contact details

The Medical School
Queen Victoria Road
Newcastle
NE1 4LP
United Kingdom

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

4628

Study information

Scientific title

A non-randomised observational trial in participants with primary osteoarthritis who will be used for mapping osteoarthritis susceptibility genes by genome-wide association scan

Acronym

arcOGEN

Study hypothesis

A collection of participants with primary osteoarthritis who will be used for mapping osteoarthritis susceptibility genes by genome-wide association scan and by other genetic approaches.

Ethics approval

Oxfordshire Research Ethics Committee (REC) C approved on the 3rd January 2008 (ref: 07/H0606/150)

Study design

Non-randomised observational trial in primary, secondary and tertiary centres

Primary study design

Observational

Secondary study design

Multi-centre

Trial setting

Other

Trial type

Screening

Patient information sheet

Not available in web format, please use the contact details below to request a patient information sheet

Condition

Topic: Musculoskeletal; Subtopic: Musculoskeletal (all Subtopics); Disease: Musculoskeletal

Intervention

There is no intervention in this trial. Recruited participants have a blood sample taken for a DNA test and a questionnaire will be answered. No treatments are given.

Intervention type

Other

Phase

Not Applicable

Drug names

Primary outcome measures

Questionnaire, completed at time of blood sampling

Secondary outcome measures

No secondary outcome measures

Overall trial start date

01/03/2008

Overall trial end date

31/12/2010

Reason abandoned

Eligibility

Participant inclusion criteria

1. Primary osteoarthritis ascertained by joint replacement of the hip or the knee
2. Male and female, lower age limit of 40 years

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

Planned Sample Size: 8000; UK Sample Size: 8000

Participant exclusion criteria

Secondary forms of osteoarthritis or non-osteoarthritic diseases that result in joint replacement surgery

Recruitment start date

01/03/2008

Recruitment end date

31/12/2010

Locations

Countries of recruitment

United Kingdom

Trial participating centre

The Medical School
Newcastle
NE1 4LP
United Kingdom

Sponsor information

Organisation

Newcastle upon Tyne Hospitals NHS Foundation Trust (UK)

Sponsor details

Wolfson Unit of Clinical Pharmacology
Institute of Cellular Medicine
Framlington Place
Newcastle
NE2 4HH
United Kingdom

Sponsor type

Hospital/treatment centre

Website

http://www.newcastle-hospitals.org.uk/

Funders

Funder type

Charity

Funder name

Arthritis Research Campaign (ARC) (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2011 results in: http://www.ncbi.nlm.nih.gov/pubmed/21177295
2012 results in: http://www.ncbi.nlm.nih.gov/pubmed/22763110

Publication citations

  1. Results

    Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Doherty M, McCaskie A, Ollier WE, Ralston SH, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Arden E, Battley K, Blackburn H, Blanco FJ, Bumpstead S, Cupples LA, Day-Williams AG, Dixon K, Doherty SA, Esko T, Evangelou E, Felson D, Gomez-Reino JJ, Gonzalez A, Gordon A, Gwilliam R, Halldorsson BV, Hauksson VB, Hofman A, Hunt SE, Ioannidis JP, Ingvarsson T, Jonsdottir I, Jonsson H, Keen R, Kerkhof HJ, Kloppenburg MG, Koller N, Lakenberg N, Lane NE, Lee AT, Metspalu A, Meulenbelt I, Nevitt MC, O'Neill F, Parimi N, Potter SC, Rego-Perez I, Riancho JA, Sherburn K, Slagboom PE, Stefansson K, Styrkarsdottir U, Sumillera M, Swift D, Thorsteinsdottir U, Tsezou A, Uitterlinden AG, van Meurs JB, Watkins B, Wheeler M, Mitchell S, Zhu Y, Zmuda JM, , Zeggini E, Loughlin J, Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study., Ann. Rheum. Dis., 2011, 70, 5, 864-867, doi: 10.1136/ard.2010.141473.

  2. Results

    , , Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O'Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Loughlin J, Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study., Lancet, 2012, 380, 9844, 815-823, doi: 10.1016/S0140-6736(12)60681-3.

Additional files

Editorial Notes