Contact information
Type
Scientific
Primary contact
Dr Neil Blumberg
ORCID ID
Contact details
601 Elmwood Avenue
Box 608
Rochester
14642
United States of America
+1 585 275 9656
neil_blumberg@urmc.rochester.edu
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
N/A
Study information
Scientific title
Acronym
Study hypothesis
Not provided at time of registration
Ethics approval
Not provided at time of registration
Study design
Randomised active controlled parallel group trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Acute Leukemia
Intervention
The control intervention was leukocyte reduced red cell and platelet transfusions, the standard practice in most hospitals.
The experimental intervention was leukocyte reduced red cell and platelet transfusions that had also been plasma reduced by washing.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
Added 14/08/09:
1. Platelet transfusion refractoriness
2. Infectious and bleeding complications
3. Overall survival.
Secondary outcome measures
Not provided at time of registration
Overall trial start date
01/01/1991
Overall trial end date
31/12/1994
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Adult patients with acute leukemia undergoing full dose remission induction chemotherapy.
Participant type
Patient
Age group
Adult
Gender
Not Specified
Target number of participants
43
Participant exclusion criteria
Does not match inclusion criteria
Recruitment start date
01/01/1991
Recruitment end date
31/12/1994
Locations
Countries of recruitment
United States of America
Trial participating centre
601 Elmwood Avenue
Rochester
14642
United States of America
Sponsor information
Organisation
University of Rochester (USA)
Sponsor details
601 Elmwood Avenue
Rochester
14642
United States of America
neil_blumberg@urmc.rochester.edu
Sponsor type
University/education
Website
Funders
Funder type
University/education
Funder name
University of Rochester (USA)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Funder name
CaridianBCT Inc. (formerly Gambro BCT Inc.) (USA)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
2004 results in http://www.ncbi.nlm.nih.gov/pubmed/15588315
Publication citations
-
Results
Blumberg N, Heal JM, Rowe JM, A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia [ISRCTN76536440]., BMC Blood Disord, 2004, 4, 1, 6, doi: 10.1186/1471-2326-4-6.