Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
AL001
Study information
Scientific title
Acronym
CHEST
Study hypothesis
Heliox + oxygen driven continuous positive airway pressure (CPAP) reduces work of breathing and improves oxygenation and carbon dioxide clearance more than air + oxygen driven CPAP
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Respiratory distress requiring CPAP
Intervention
Heliox + oxygen driven continuous positive airway pressure (CPAP) versus air + oxygen driven CPAP.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Work of breathing
Secondary outcome measures
Oxygenation, carbon dioxide clearance
Overall trial start date
01/09/2005
Overall trial end date
01/03/2007
Reason abandoned
Lack of funding
Eligibility
Participant inclusion criteria
Children under 1 year of age with respiratory distress requiring CPAP
Participant type
Patient
Age group
Child
Gender
Both
Target number of participants
20
Participant exclusion criteria
Refusing consent, pneumothorax, FiO2 >0.6, imminent intubation, respiratory failure
Recruitment start date
01/09/2005
Recruitment end date
01/03/2007
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Imperial College London
London
W21PG
United Kingdom
Funders
Funder type
Industry
Funder name
Gas will be provided by BOC Ltd. Equipment and application fees will be provided by Viasys
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary