Contact information
Type
Scientific
Primary contact
Dr E Corbett
ORCID ID
Contact details
London School of Hygiene and Tropical Medicine
Department of Infectious and Tropical Diseases
Keppel Street
London
WC1E 7HT
United Kingdom
+44 (0)20 7927 2116
elizabeth.corbett@lshtm.ac.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
074644; LSHTM ITCR BA79
Study information
Scientific title
A cluster randomised trial of two intensified tuberculosis case-finding strategies in an urban community severely affected by human immunodeficiency virus
Acronym
DETECTB
Study hypothesis
1. To compare the cumulative yield and residual burden of two potentially sustainable intensified TB case-finding methods applied for 3 years in a high HIV setting
2. To investigate HIV-specific point prevalence and incidence of active TB disease in an urban community before and after the intervention period (as of 13/02/2007 this hypothesis was changed to 'To investigate the change in point prevalence of culture-positive TB disease in an urban community before and after the intervention period')
On 13/02/2007 the overall trial end date was changed to 01/12/2008.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Tuberculosis
Intervention
Cluster-randomised trial of high density neighbourhoods in Zimbabwe
Randomisation unit: each neighbourhood site
Number of sites: 46
Each neighbourhood is randomised to receive either mobile clinic or door-to-door enquiry.
Open cohort of all adults living in households within study neighbourhoods (~120,000 in total). Stratified randomisation according to pre-intervention TB case-notification rates.
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measure
Cumulative yield of TB cases detected through six rounds of periodic (six-monthly) case-finding intervention delivered through either:
1. House-to-house enquiry for chronic coughers
2. Mobile diagnostic clinic visits
Secondary outcome measures
HIV-specific point prevalence and incidence of active TB disease before and immediately after the intervention (for whole study area with both arms combined) - as of 13/02/2007 this secondary outcome measure was changed to: 'Point prevalence of culture-positive TB disease before and immediately after the intervention (for whole study area with both arms combined)'.
Overall trial start date
01/02/2006
Overall trial end date
01/12/2008
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Site:
1. Study neighbourhoods based on Census Evaluation Units (CEUs) in residential suburbs of South-West and Western Harare
2. Three to four CEUs combined to provide:
a. 2000-3000 adults registered for 2002 Census
b. No flats or Halls of Residence
c. At least 500 km distance between study neighbourhoods
All eligible neighbourhoods included
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
120,000 - 110,000 as of 07/08/2006 (end of recruitment)
Participant exclusion criteria
Individual:
1. Declined consent to participate
2. Aged below 16 years
Recruitment start date
01/02/2006
Recruitment end date
07/08/2006
Locations
Countries of recruitment
Zimbabwe
Trial participating centre
London School of Hygiene and Tropical Medicine
London
WC1E 7HT
United Kingdom
Sponsor information
Organisation
London School of Hygiene and Tropical Medicine (UK)
Sponsor details
Keppel Street
London
WC1E 7HT
United Kingdom
+44 (0)20 7636 8636
Penny.Ireland@lshtm.ac.uk
Sponsor type
University/education
Website
Funders
Funder type
Charity
Funder name
Wellcome Trust (UK) (grant ref: 074644)
Alternative name(s)
Funding Body Type
unknown
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Basic results (scientific)
Publication list
2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20923715
Publication citations
-
Results
Corbett EL, Bandason T, Duong T, Dauya E, Makamure B, Churchyard GJ, Williams BG, Munyati SS, Butterworth AE, Mason PR, Mungofa S, Hayes RJ, Comparison of two active case-finding strategies for community-based diagnosis of symptomatic smear-positive tuberculosis and control of infectious tuberculosis in Harare, Zimbabwe (DETECTB): a cluster-randomised trial., Lancet, 2010, 376, 9748, 1244-1253, doi: 10.1016/S0140-6736(10)61425-0.