Condition category
Respiratory
Date applied
03/08/2006
Date assigned
31/08/2006
Last edited
14/12/2010
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Dr Nick Oscroft

ORCID ID

Contact details

Papworth Hospital
Papworth Everard
Cambridge
CB3 8RE
United Kingdom
+44 (0)1480 364495
nick.oscroft@papworth.nhs.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

P01033

Study information

Scientific title

Acronym

Study hypothesis

Auto Variable Positive Airway Pressure (AutoVPAP) is not as efficacious as Non-Invasive Positive Pressure Ventilation (NIPPV).

Ethics approval

Approved by Huntingdon Research Ethics Committee (REC) on 5/09/2006 (reference number: 05/Q0104/118).

Study design

Randomised crossover trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Hospitals

Trial type

Treatment

Patient information sheet

Condition

Chronic Obstructive Pulmonary Disease (COPD)

Intervention

AutoVPAP versus NIPPV

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Nocturnal oxygenation

Secondary outcome measures

Quality of life

Overall trial start date

15/12/2005

Overall trial end date

15/12/2006

Reason abandoned

Eligibility

Participant inclusion criteria

1. Chronic Obstructive Pulmonary Disease (COPD)
2. Forced Expiratory Volume in One second (FEV1) more than 50% predicted value
3. Smoking history more than 20 pack years

Participant type

Patient

Age group

Senior

Gender

Both

Target number of participants

25

Participant exclusion criteria

1. Aged over 80 years
2. No other significant lung disease

Recruitment start date

15/12/2005

Recruitment end date

15/12/2006

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Papworth Hospital
Cambridge
CB3 8RE
United Kingdom

Sponsor information

Organisation

Papworth Hospital NHS Foundation Trust (UK)

Sponsor details

Papworth Hospital
Papworth Everard
Cambridge
CB3 8RE
United Kingdom

Sponsor type

Government

Website

Funders

Funder type

Industry

Funder name

ResMed

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20546195

Publication citations

  1. Results

    Oscroft NS, Quinnell TG, Shneerson JM, Smith IE, Long-term non-invasive ventilation to manage persistent ventilatory failure after COPD exacerbation., Respirology, 2010, 15, 5, 818-822, doi: 10.1111/j.1440-1843.2010.01787.x.

Additional files

Editorial Notes