Contact information
Type
Scientific
Primary contact
Dr Nick Oscroft
ORCID ID
Contact details
Papworth Hospital
Papworth Everard
Cambridge
CB3 8RE
United Kingdom
+44 (0)1480 364495
nick.oscroft@papworth.nhs.uk
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
P01033
Study information
Scientific title
Acronym
Study hypothesis
Auto Variable Positive Airway Pressure (AutoVPAP) is not as efficacious as Non-Invasive Positive Pressure Ventilation (NIPPV).
Ethics approval
Approved by Huntingdon Research Ethics Committee (REC) on 5/09/2006 (reference number: 05/Q0104/118).
Study design
Randomised crossover trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Hospitals
Trial type
Treatment
Patient information sheet
Condition
Chronic Obstructive Pulmonary Disease (COPD)
Intervention
AutoVPAP versus NIPPV
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Nocturnal oxygenation
Secondary outcome measures
Quality of life
Overall trial start date
15/12/2005
Overall trial end date
15/12/2006
Reason abandoned
Eligibility
Participant inclusion criteria
1. Chronic Obstructive Pulmonary Disease (COPD)
2. Forced Expiratory Volume in One second (FEV1) more than 50% predicted value
3. Smoking history more than 20 pack years
Participant type
Patient
Age group
Senior
Gender
Both
Target number of participants
25
Participant exclusion criteria
1. Aged over 80 years
2. No other significant lung disease
Recruitment start date
15/12/2005
Recruitment end date
15/12/2006
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Papworth Hospital
Cambridge
CB3 8RE
United Kingdom
Funders
Funder type
Industry
Funder name
ResMed
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
1. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20546195
Publication citations
-
Results
Oscroft NS, Quinnell TG, Shneerson JM, Smith IE, Long-term non-invasive ventilation to manage persistent ventilatory failure after COPD exacerbation., Respirology, 2010, 15, 5, 818-822, doi: 10.1111/j.1440-1843.2010.01787.x.