Condition category
Circulatory System
Date applied
27/03/2003
Date assigned
27/03/2003
Last edited
25/09/2009
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Professor Ian Jacobs

ORCID ID

Contact details

Department of Emergency Medicine
University of Western Australia
35 Stirling Hwy
Nedlands
6009
Australia
+61 8 9346 4354
ijacobs@cyllene.uwa.edu.au

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

RA/4/1/0029

Study information

Scientific title

Acronym

Study hypothesis

90 seconds of CPR before defibrillation improves survival in patients suffering a cardaic arrest outside of hospital.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Not Specified

Patient information sheet

Condition

Cardiac Arrest

Intervention

Patients meeting the above criteria were randomised to receive either defibrillation as soon as possible in line with existing treatment guidelines (Control arm) or 90 seconds of oxygen supplemented CPR before defibrillation (Experimental arm).

Primary outcomes assessed include return of spontaneous circulation (ROSC), survival to hospital discharge and neurological status (Cerebral Performance Category).

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Survival to hospital discharge.

Secondary outcome measures

1. Return of spontaneous circulation.
2. Survival at one year

Overall trial start date

01/06/2000

Overall trial end date

30/06/2002

Reason abandoned

Eligibility

Participant inclusion criteria

All patients older than 16 years suffering cardiac arrest outside of hospital in which the underlying cardiac rhythm was ventricular fibrillation upon arrival of Ambulance Paramedics

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

256

Participant exclusion criteria

1. Patients with known allergies to Fentanyl
2. Patients unable to receive intranasal fentanyl due to facial and / or nasal trauma
3. Patients who are pregnant

Recruitment start date

01/06/2000

Recruitment end date

30/06/2002

Locations

Countries of recruitment

Australia

Trial participating centre

Department of Emergency Medicine
Nedlands
6009
Australia

Sponsor information

Organisation

Western Australian Prehospital Care Research Unit (Australia)

Sponsor details

Department of Emergency Medicine
University of Western Australia
Nedlands
6009
Australia

Sponsor type

Hospital/treatment centre

Website

http://www.uwa.edu.au/

Funders

Funder type

Charity

Funder name

National Heart Foundation of Australia (Australia)

Alternative name(s)

Heart Foundation

Funding Body Type

private sector organisation

Funding Body Subtype

foundation

Location

Australia

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2005 results in http://www.ncbi.nlm.nih.gov/pubmed/15675903

Publication citations

  1. Results

    Jacobs IG, Finn JC, Oxer HF, Jelinek GA, CPR before defibrillation in out-of-hospital cardiac arrest: a randomized trial., Emerg Med Australas, 2005, 17, 1, 39-45, doi: 10.1111/j.1742-6723.2005.00694.x.

Additional files

Editorial Notes