A randomised clinical trial of cardiopulmonary resuscitation (CPR) prior to defibrillation for the treatment of out-of-hospital ventricular fibrillation

ISRCTN	ISRCTN87778564
DOI	https://doi.org/10.1186/ISRCTN87778564
Protocol serial number	RA/4/1/0029
Sponsor	Western Australian Prehospital Care Research Unit (Australia)
Funder	National Heart Foundation of Australia (Australia)

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English summary of protocol

Not provided at time of registration

Prof Ian Jacobs
Scientific

Department of Emergency Medicine
University of Western Australia
35 Stirling Hwy
Nedlands
6009
Australia

Phone	+61 8 9346 4354
Email	ijacobs@cyllene.uwa.edu.au

Primary study design	Interventional
Study design	Randomised controlled trial
Secondary study design	Randomised controlled trial
Scientific title
Study objectives	90 seconds of CPR before defibrillation improves survival in patients suffering a cardaic arrest outside of hospital.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Cardiac Arrest
Intervention	Patients meeting the above criteria were randomised to receive either defibrillation as soon as possible in line with existing treatment guidelines (Control arm) or 90 seconds of oxygen supplemented CPR before defibrillation (Experimental arm). Primary outcomes assessed include return of spontaneous circulation (ROSC), survival to hospital discharge and neurological status (Cerebral Performance Category).
Intervention type	Other
Primary outcome measure(s)	Survival to hospital discharge.
Key secondary outcome measure(s)	1. Return of spontaneous circulation. 2. Survival at one year
Completion date	30/06/2002

Participant type(s)	Patient
Age group	Adult
Sex	All
Target sample size at registration	256
Key inclusion criteria	All patients older than 16 years suffering cardiac arrest outside of hospital in which the underlying cardiac rhythm was ventricular fibrillation upon arrival of Ambulance Paramedics
Key exclusion criteria	1. Patients with known allergies to Fentanyl 2. Patients unable to receive intranasal fentanyl due to facial and / or nasal trauma 3. Patients who are pregnant
Date of first enrolment	01/06/2000
Date of final enrolment	30/06/2002

Department of Emergency Medicine

Nedlands
6009
Australia

Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Date added	Peer reviewed?	Patient-facing?
Results article	results	01/02/2005		Yes	No