A randomised clinical trial of cardiopulmonary resuscitation (CPR) prior to defibrillation for the treatment of out-of-hospital ventricular fibrillation
| ISRCTN | ISRCTN87778564 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN87778564 |
| Secondary identifying numbers | RA/4/1/0029 |
- Submission date
- 27/03/2003
- Registration date
- 27/03/2003
- Last edited
- 25/09/2009
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English summary of protocol
Not provided at time of registration
Contact information
Professor Ian Jacobs
Scientific
Scientific
Department of Emergency Medicine
University of Western Australia
35 Stirling Hwy
Nedlands
6009
Australia
| Phone | +61 8 9346 4354 |
|---|---|
| ijacobs@cyllene.uwa.edu.au |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Not Specified |
| Scientific title | |
| Study objectives | 90 seconds of CPR before defibrillation improves survival in patients suffering a cardaic arrest outside of hospital. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Cardiac Arrest |
| Intervention | Patients meeting the above criteria were randomised to receive either defibrillation as soon as possible in line with existing treatment guidelines (Control arm) or 90 seconds of oxygen supplemented CPR before defibrillation (Experimental arm). Primary outcomes assessed include return of spontaneous circulation (ROSC), survival to hospital discharge and neurological status (Cerebral Performance Category). |
| Intervention type | Other |
| Primary outcome measure | Survival to hospital discharge. |
| Secondary outcome measures | 1. Return of spontaneous circulation. 2. Survival at one year |
| Overall study start date | 01/06/2000 |
| Completion date | 30/06/2002 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 256 |
| Key inclusion criteria | All patients older than 16 years suffering cardiac arrest outside of hospital in which the underlying cardiac rhythm was ventricular fibrillation upon arrival of Ambulance Paramedics |
| Key exclusion criteria | 1. Patients with known allergies to Fentanyl 2. Patients unable to receive intranasal fentanyl due to facial and / or nasal trauma 3. Patients who are pregnant |
| Date of first enrolment | 01/06/2000 |
| Date of final enrolment | 30/06/2002 |
Locations
Countries of recruitment
- Australia
Study participating centre
Department of Emergency Medicine
Nedlands
6009
Australia
6009
Australia
Sponsor information
Western Australian Prehospital Care Research Unit (Australia)
Hospital/treatment centre
Hospital/treatment centre
Department of Emergency Medicine
University of Western Australia
Nedlands
6009
Australia
| Website | http://www.uwa.edu.au/ |
|---|
Funders
Funder type
Charity
National Heart Foundation of Australia (Australia)
Private sector organisation / Trusts, charities, foundations (both public and private)
Private sector organisation / Trusts, charities, foundations (both public and private)
- Alternative name(s)
- Heart Foundation
- Location
- Australia
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/02/2005 | Yes | No |
