Contact information
Type
Scientific
Primary contact
Professor Ian Jacobs
ORCID ID
Contact details
Department of Emergency Medicine
University of Western Australia
35 Stirling Hwy
Nedlands
6009
Australia
+61 8 9346 4354
ijacobs@cyllene.uwa.edu.au
Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
RA/4/1/0029
Study information
Scientific title
Acronym
Study hypothesis
90 seconds of CPR before defibrillation improves survival in patients suffering a cardaic arrest outside of hospital.
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Not Specified
Patient information sheet
Condition
Cardiac Arrest
Intervention
Patients meeting the above criteria were randomised to receive either defibrillation as soon as possible in line with existing treatment guidelines (Control arm) or 90 seconds of oxygen supplemented CPR before defibrillation (Experimental arm).
Primary outcomes assessed include return of spontaneous circulation (ROSC), survival to hospital discharge and neurological status (Cerebral Performance Category).
Intervention type
Other
Phase
Not Specified
Drug names
Primary outcome measures
Survival to hospital discharge.
Secondary outcome measures
1. Return of spontaneous circulation.
2. Survival at one year
Overall trial start date
01/06/2000
Overall trial end date
30/06/2002
Reason abandoned
Eligibility
Participant inclusion criteria
All patients older than 16 years suffering cardiac arrest outside of hospital in which the underlying cardiac rhythm was ventricular fibrillation upon arrival of Ambulance Paramedics
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
256
Participant exclusion criteria
1. Patients with known allergies to Fentanyl
2. Patients unable to receive intranasal fentanyl due to facial and / or nasal trauma
3. Patients who are pregnant
Recruitment start date
01/06/2000
Recruitment end date
30/06/2002
Locations
Countries of recruitment
Australia
Trial participating centre
Department of Emergency Medicine
Nedlands
6009
Australia
Sponsor information
Organisation
Western Australian Prehospital Care Research Unit (Australia)
Sponsor details
Department of Emergency Medicine
University of Western Australia
Nedlands
6009
Australia
Sponsor type
Hospital/treatment centre
Website
Funders
Funder type
Charity
Funder name
National Heart Foundation of Australia (Australia)
Alternative name(s)
Heart Foundation
Funding Body Type
private sector organisation
Funding Body Subtype
foundation
Location
Australia
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
2005 results in http://www.ncbi.nlm.nih.gov/pubmed/15675903
Publication citations
-
Results
Jacobs IG, Finn JC, Oxer HF, Jelinek GA, CPR before defibrillation in out-of-hospital cardiac arrest: a randomized trial., Emerg Med Australas, 2005, 17, 1, 39-45, doi: 10.1111/j.1742-6723.2005.00694.x.