Condition category
Musculoskeletal Diseases
Date applied
Date assigned
Last edited
Retrospectively registered
Overall trial status
Recruitment status
No longer recruiting
Publication status
Results overdue

Plain English Summary

Not provided at time of registration

Trial website

Contact information



Primary contact

Dr Iain Moppett


Contact details

Department of Anaesthesia and Intensive Care
Queens Medical Centre
United Kingdom

Additional identifiers

EudraCT number number

Protocol/serial number


Study information

Scientific title

Feasibility and metabolic effects of carbohydrate loading in patients with fragility hip fracture - a randomised double blind pilot study


Pre-operative Nutrition In Neck of femur Trial (POINT)

Study hypothesis

Hip fracture is a common injury affecting predominantly old people. The outcome for patients is often poor with a high mortality following operation, and worsening of mobility and function when compared with that before the injury.It has long been recognized that trauma due to surgery or accident is associated with changes in the way muscles use fuels such as sugar (glucose). These changes come on soon after injury and persist for some time and may have harmful effects on recovery and muscle strength. We also know that poor muscle function is a predictor of poor outcome in the days and months following hip fracture. Researchers in the field of elective surgery have found that providing patients with special carbohydrate drinks before their operation can improve muscle sugar use and have beneficial effects in the postoperative period.However, due to the nature of hip fracture, which is operated on urgently, and in a frail population who are often in pain, providing preoperative drinks may be difficult. The muscle of older people behaves differently to that of younger people so we don't know whether these drinks will have the same effect. Potentially, if we can find out what effect these drinks have on the way muscles behave; this may provide avenues of future research into the optimal way to enhance muscle function following hip fracture. To do this, we wish to study a group of hip fracture patients. We wish to find out what happens to the way their bodies deal with sugar if they have these drinks or if they have normal care without the drinks. We would do this by simple blood tests, and by taking some small tissue samples from leg muscles before and after their operation. Part of the study will also be looking at the practical issues around providing these sorts of drinks to this patient group.

Ethics approval

East Midlands - Nottingham 1 Research Ethics Committee, 15/07/2013, ref: 13/EM/0214

Study design

Randomised; Interventional; Design type: Not specified, Prevention

Primary study design


Secondary study design

Randomised controlled trial

Trial setting


Trial type


Patient information sheet


Enhancement of recovery following hip fracture surgery


Pre-op carbohydrate drink, Nutricia Pre-op(r)
400 ml night before surgery
400 ml morning of surgery (up to 2 hours pre-op)

Follow Up Length: 1 month(s); Study Entry: Single Randomisation only

Intervention type



Not Applicable

Drug names

Primary outcome measure

Oral glucose tolerance test; Timepoint(s): Day 1 post operation

Secondary outcome measures

1. Glucose homeostasis - blood glucose; Timepoint(s): Blood glucose prior to induction of anaesthesia
2. Blood glucose on day 1; Glucose homeostasis - insulin; Timepoint(s): Insulin concentration - prior to induction of anaesthesia, Insulin concentration - day 1 post op
3. Length of acute hospital stay; Timepoint(s): Hospital discharge
4. Mobility - Cumulated ambulation score; Timepoint(s): Days 1-3 post-op
5. Muscle metabolism - muscle biopsy, contralateral leg; Timepoint(s): Prior to induction of anaesthesia At end of surgery
Day 1
6. Nausea and vomiting; Timepoint(s): Prior to induction of anaesthesia Day 1 post-operation

Overall trial start date


Overall trial end date


Reason abandoned (if study stopped)


Participant inclusion criteria

1. Patients presenting through accident and emergency with a fragility neck of femur fracture requiring hemiarthroplasty
2. Aged 70 or over
3. Patients able to provide fully informed consent

Participant type


Age group




Target number of participants

Planned Sample Size: 30; UK Sample Size: 30; Description: Allow for 3 drop outs per group (20% drop out)

Participant exclusion criteria

1. Patients who are confused or unable to give their own consent
2. Patient known to suffer with diabetes (either type 1 or type 2)
3. Patients with current infections
4. Ongoing participation in another clinical trial
5. Multiple injuries requiring operative management
6. Previous intolerance to carbohydrate drinks

Recruitment start date


Recruitment end date



Countries of recruitment

United Kingdom

Trial participating centre

Queens Medical Centre
United Kingdom

Sponsor information


University of Nottingham (UK)

Sponsor details

Research Innovation Services
Kings Meadow Campus
Lenton Lane
United Kingdom

Sponsor type




Funder type

Research organisation

Funder name

British Journal of Anaesthesia (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype


Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Basic results (scientific)

Publication list

2014 protocol in:

Publication citations

Additional files

Editorial Notes

12/08/2020: No publications found. 13/03/2020: Internal review. 21/11/2018: No publications found, verifying study status with principal investigator.