Condition category
Injury, Occupational Diseases, Poisoning
Date applied
06/08/2003
Date assigned
07/08/2003
Last edited
06/05/2014
Prospective/Retrospective
Prospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Mr John Stapleton

ORCID ID

Contact details

Institute Of Psychiatry
Kings College London
Postal Box P075
4 Windsor Walk
London
SE5 8AF
United Kingdom
+44 (0)20 7848 0450
j.stapleton@iop.kcl.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

G0200455

Study information

Scientific title

Acronym

ZORN

Study hypothesis

To compare effectiveness of the three treatments in routine National Health Service (NHS) care.

Ethics approval

Not provided at time of registration

Study design

Randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Tobacco dependence

Intervention

Group and individual specialist counselling over six weeks, plus NRT, bupropion or both

Intervention type

Drug

Phase

Not Specified

Drug names

Bupropion

Primary outcome measures

Smoking status at four weeks and 12 months

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/05/2004

Overall trial end date

30/06/2007

Reason abandoned

Eligibility

Participant inclusion criteria

All smokers eligible to use Nicotine Replacement Therapy (NRT) and bupropion who present for help to stop smoking

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

1800

Participant exclusion criteria

Those with contraindications for NRT or bupropion

Recruitment start date

01/05/2004

Recruitment end date

30/06/2007

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Institute Of Psychiatry
London
SE5 8AF
United Kingdom

Sponsor information

Organisation

King's College London (UK)

Sponsor details

Institute of Psychiatry
De Crespigny Park
London
SE5 8AF
United Kingdom

Sponsor type

University/education

Website

http://www.iop.kcl.ac.uk/

Funders

Funder type

Government

Funder name

Department of Health (UK)

Alternative name(s)

Funding Body Type

Funding Body Subtype

Location

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/23859696

Publication citations

  1. Results

    Stapleton J, West R, Hajek P, Wheeler J, Vangeli E, Abdi Z, O'Gara C, McRobbie H, Humphrey K, Ali R, Strang J, Sutherland G, Randomized trial of nicotine replacement therapy (NRT), bupropion and NRT plus bupropion for smoking cessation: effectiveness in clinical practice., Addiction, 2013, 108, 12, 2193-2201, doi: 10.1111/add.12304.

Additional files

Editorial Notes