Additional identifiers
EudraCT number
ClinicalTrials.gov number
Protocol/serial number
71887897
Study information
Scientific title
Acronym
WHIFF-AD
Study hypothesis
Aromatherapy is as effective as standard treatment for agitation in Alzheimer's disease
Ethics approval
Not provided at time of registration
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Trial setting
Not specified
Trial type
Treatment
Patient information sheet
Condition
Alzheimer's disease
Intervention
Aromatherapy versus standard treatment
Intervention type
Drug
Phase
Not Specified
Drug names
Aromatherapy
Primary outcome measures
Reduction in agitation
Secondary outcome measures
Side effect profile
Overall trial start date
01/02/2006
Overall trial end date
01/02/2009
Reason abandoned
Eligibility
Participant inclusion criteria
Alzheimer's disease with agitation
Participant type
Patient
Age group
Adult
Gender
Both
Target number of participants
150
Participant exclusion criteria
Failure to meet inclusion criteria
Recruitment start date
01/02/2006
Recruitment end date
01/02/2009
Locations
Countries of recruitment
United Kingdom
Trial participating centre
Wythenshawe Hospital
Manchester
M23 9LT
United Kingdom
Funders
Funder type
Charity
Funder name
Alzheimer's Society
Alternative name(s)
Funding Body Type
private sector organisation
Funding Body Subtype
professional associations and societies
Location
United Kingdom
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Participant level data
Not provided at time of registration
Results - basic reporting
Publication summary
1. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21335973
Publication citations
-
Results
Burns A, Perry E, Holmes C, Francis P, Morris J, Howes MJ, Chazot P, Lees G, Ballard C, A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease., Dement Geriatr Cogn Disord, 2011, 31, 2, 158-164, doi: 10.1159/000324438.