Condition category
Nervous System Diseases
Date applied
23/10/2000
Date assigned
23/10/2000
Last edited
23/07/2012
Prospective/Retrospective
Retrospectively registered
Overall trial status
Completed
Recruitment status
No longer recruiting

Plain English Summary

Not provided at time of registration

Trial website

Contact information

Type

Scientific

Primary contact

Prof David Chadwick

ORCID ID

Contact details

Department of Neurological Science
The Walton Centre
Lower Lane
Fazakerley
Liverpool
L9 7LJ
United Kingdom
+44 (0)151 529 5461
dwc@liv.ac.uk

Additional identifiers

EudraCT number

ClinicalTrials.gov number

Protocol/serial number

G9125371

Study information

Scientific title

Acronym

MESS

Study hypothesis

1. To compare seizure recurrence rates associated with policies of immediate or delayed antiepileptic drug therapy in patients with single seizures and early epilepsy using a pragmatic randomized parallel group design.
2. To identify factors of prognostic importance in the recurrence of seizures in the early course of epilepsy
3. To examine the psychosocial outcome of the two randomized policies

Ethics approval

Not provided at time of registration

Study design

Multicentre randomised controlled trial

Primary study design

Interventional

Secondary study design

Randomised controlled trial

Trial setting

Not specified

Trial type

Treatment

Patient information sheet

Condition

Epilepsy

Intervention

Immediate/delayed antiepileptic drug therapy

Intervention type

Other

Phase

Not Specified

Drug names

Primary outcome measures

Time to first seizure, time to remission, patient perceived quality of life

Secondary outcome measures

Not provided at time of registration

Overall trial start date

01/01/1993

Overall trial end date

31/12/2002

Reason abandoned

Eligibility

Participant inclusion criteria

1. An adequately documented recent history of one or more clinically definite spontaneous unprovoked epileptic seizures
2. Clinician is uncertain whether to treat or not

Participant type

Patient

Age group

Adult

Gender

Both

Target number of participants

1800

Participant exclusion criteria

Not provided at time of registration

Recruitment start date

01/01/1993

Recruitment end date

31/12/2002

Locations

Countries of recruitment

United Kingdom

Trial participating centre

Department of Neurological Science
Liverpool
L9 7LJ
United Kingdom

Sponsor information

Organisation

Medical Research Council (MRC) (UK)

Sponsor details

20 Park Crescent
London
W1B 1AL
United Kingdom
+44 20 7636 5422
clinical.trial@headoffice.mrc.ac.uk

Sponsor type

Research council

Website

http://www.mrc.ac.uk

Funders

Funder type

Research council

Funder name

Medical Research Council

Alternative name(s)

MRC

Funding Body Type

private sector organisation

Funding Body Subtype

other non-profit

Location

United Kingdom

Results and Publications

Publication and dissemination plan

Not provided at time of registration

Intention to publish date

Participant level data

Not provided at time of registration

Results - basic reporting

Publication summary

1. 2005 results in http://www.ncbi.nlm.nih.gov/pubmed/15950714
2. 2006 results in http://www.ncbi.nlm.nih.gov/pubmed/16545748
3. 2006 results in http://www.ncbi.nlm.nih.gov/pubmed/17130429
4. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/21147743
5. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22696580

Publication citations

  1. Results

    Marson A, Jacoby A, Johnson A, Kim L, Gamble C, Chadwick D, , Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial., Lancet, 365, 9476, 2007-2013, doi: 10.1016/S0140-6736(05)66694-9.

  2. Results

    Kim LG, Johnson TL, Marson AG, Chadwick DW, , Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial., Lancet Neurol, 2006, 5, 4, 317-322, doi: 10.1016/S1474-4422(06)70383-0.

  3. Results

    Marson AG, Williamson PR, Taylor S, Maguire M, Chadwick DW, Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures., Neurology, 2006, 67, 10, 1872-1875, doi: 10.1212/01.wnl.0000244421.73986.09.

  4. Results

    Bonnett LJ, Tudur-Smith C, Williamson PR, Marson AG, Risk of recurrence after a first seizure and implications for driving: further analysis of the Multicentre study of early Epilepsy and Single Seizures., BMJ, 2010, 341, c6477.

  5. Results

    Rogers JK, Hutton J, Marson AG, Chadwick DW, Assessing the risk of subsequent tonic-clonic seizures in patients with a history of simple or complex partial seizures., J. Neurol. Neurosurg. Psychiatr., 2012, 83, 8, 803-809, doi: 10.1136/jnnp-2011-300917.

Additional files

Editorial Notes