Can children in hospital safely switch from antibiotics given through a vein to antibiotics taken by mouth? A study to assess whether this approach is practical, effective, and can reduce hospital stay and treatment costs in Egypt

1. Approved 09/04/2026, Cairo University, Faculty of Medicine, Research Ethics Commitee (Kasr Al Aini, Cairo University, Cairo, 12613, Egypt; +20 2 35674835; kasralainyrec@kasralainy.edu.eg), ref: N-63-2026

2. Approved 05/06/2026, Huddersfield University, School of Applied Sciences Research Integrity and Ethics Committee (School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, United Kingdom; +44 1484422288; sas_ethics@hud.ac.uk), ref: SAS-SRIEC-05.06.2026WE_2

1. Duration of IV and PO antibiotic therapy (days) measured using Medical record review at Baseline, day of eligibility of IV-to-PO switch, during the 7 days after conversion, day 14 follow-up
2. Total antibiotic duration (days) measured using Medical record review at Baseline, day of eligibility of IV-to-PO switch, during the 7 days after conversion, day 14 follow-up
3. Length of hospital stay (days) measured using Hospital administrative records at Baseline, day of eligibility of IV-to-PO switch, day 14 follow-up
4. Treatment success rate measured using Clinical assessment documented in medical records at Day of eligibility of IV-to-PO switch, during the 7 days after conversion, day 14 follow-up
5. Rate of antibiotic-related adverse events measured using Adverse event reporting in medical records at Baseline, during the 7 days after conversion, day 14 follow-up
6. Rate of recurrence within 14 days measured using Clinical assessment documented in medical records at Day 14 follow-up
7. Rate of reconverted patients to IV therapy measured using Medical record review at During the 7 days after conversion, day 14 follow-up