Accelerating tooth movement with platelet-rich plasma
| ISRCTN | ISRCTN12537093 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN12537093 |
- Submission date
- 18/08/2024
- Registration date
- 27/08/2024
- Last edited
- 27/08/2024
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Oral Health
Plain English summary of protocol
Background and study aims
This study aimed to evaluate the effectiveness of platelet-rich plasma (PRP) in accelerating orthodontic tooth movement and reducing treatment duration.
Who can participate?
Patients aged 18 to 25 years with anterior teeth crowding.
What does the study involve?
Patients were randomly assigned to either the PRP group or the control group. The PRP group received PRP injections at 0, 7, and 14 days, while the control group received standard orthodontic treatment without additional interventions.
What are the possible benefits and risks of participating?
This study will evaluate the efficiency of using PRP injection to accelerate orthodontic tooth movement. There is a risk of not achieving optimal results in some cases but the study team can manage these cases with alternative methods.
Where is the study run from?
Tishreen University (Syria)
When is the study starting and how long is it expected to run for?
November 2021 to August 2023
Who is funding the study?
Damascus University (Syria)
Who is the main contact?
Dr May Alel, drmayakel@gmail.com
Contact information
Public, Scientific, Principal Investigator
Damascus University
Mazzeh Highway
Damascus
-
Syria
 ORCID ID |
0009-0005-4736-7840 |
|---|---|
| Phone | +963 992964458 |
| drmayakel@gmail.com |
Study information
| Study design | Comparative interventional randomized controlled study |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | University/medical school/dental school |
| Study type | Quality of life, Treatment, Efficacy |
| Participant information sheet | Not available in web format, please use the contact details to request a participant information sheet |
| Scientific title | Enhancing orthodontic treatment efficiency with platelet-rich plasma: a randomized controlled trial |
| Study objectives | Can platelet-rich plasma (PRP) accelerate orthodontic tooth movement? |
| Ethics approval(s) |
Approved 07/12/2021, Damascus University ethics committee (Mazzeh Highway, Damascus, -, Syria; +963 (0) 113341864; manager@hcsr.gov.sy), ref: 22486 |
| Health condition(s) or problem(s) studied | Anterior teeth crowding |
| Intervention | Patients were randomly assigned to either the PRP group or the control group. The PRP group received PRP injections at 0, 7, and 14 days, while the control group received standard orthodontic treatment without additional interventions. |
| Intervention type | Procedure/Surgery |
| Primary outcome measure | Little’s Irregularity Index: Dental models were obtained at four key stages: initial (T0), 5 weeks after beginning treatment (T1), 8 weeks into treatment (T2), and 10 weeks into treatment (T3). The Little’s Irregularity Index was calculated with precision using a digital caliper to measure the distances between the contact points of the six anterior maxillary teeth. |
| Secondary outcome measures | The duration of the orthodontic treatment was recorded in months, starting with the bonding of 0.022-inch brackets and concluding with the application of a 0.017 x 0.025-inch stainless steel archwire. |
| Overall study start date | 13/11/2021 |
| Completion date | 23/08/2023 |
Eligibility
| Participant type(s) | Healthy volunteer |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Upper age limit | 25 Years |
| Sex | Both |
| Target number of participants | 40 |
| Total final enrolment | 40 |
| Key inclusion criteria | 1. Eligible participants were individuals aged 18 to 25 years 2. The study focused on patients with anterior teeth crowding ranging from 3 to 6 mm 3. A prerequisite for inclusion was the maintenance of excellent oral hygiene and periodontal status 4. Candidates with no prior orthodontic treatment history were included |
| Key exclusion criteria | 1. Individuals with any systemic medical conditions were not considered for the study 2. Excluded were patients with dental anomalies in tooth size or shape 3. The study did not include patients with skeletal discrepancies in the vertical, transverse, or anteroposterior dimensions 4. Those currently taking anti-inflammatory medications were also excluded from participation |
| Date of first enrolment | 01/01/2022 |
| Date of final enrolment | 01/01/2023 |
Locations
Countries of recruitment
- Syria
Study participating centre
Department of Orthodontics
Latakia
-
Syria
Sponsor information
University/education
Mazzeh Highway
Damascus
-
Syria
| Phone | +963 (0)113341864 |
|---|---|
| manager@hcsr.gov.sy | |
| Website | http://www.damascusuniversity.edu.sy |
"ROR" |
https://ror.org/03m098d13 |
Funders
Funder type
University/education
Government organisation / Universities (academic only)
- Alternative name(s)
- University of Damascus, جَامِعَةُ دِمَشْقَ, DU
- Location
- Syria
Results and Publications
| Intention to publish date | 31/12/2024 |
|---|---|
| Individual participant data (IPD) Intention to share | Yes |
| IPD sharing plan summary | Available on request |
| Publication and dissemination plan | Planned publication in a peer-reviewed journal |
| IPD sharing plan | The datasets generated during and/or analysed during the current study will be available on request from Dr May Alel (drmayakel@gmail.com) and in the publication related to it after the end of the research. |
Editorial Notes
23/08/2024: Study's existence confirmed by Tishreen University.
