Measuring adrenaline release in the first few minutes after severe injury in motorcycle racers
| ISRCTN | ISRCTN15243764 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN15243764 |
| Secondary identifying numbers | 174 |
- Submission date
- 23/05/2025
- Registration date
- 11/06/2025
- Last edited
- 27/05/2025
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Injury, Occupational Diseases, Poisoning
Plain English summary of protocol
To measure the levels of Adrenaline, Nor-Adrenaline & dopamine in motorcycle racers who have been injured, within the first few minutes and compare it with levels on arrival to the Emergency department. We will also compare it to Injury severity score (ISS)
Background and study aims
Anecdotal experience from prehospital providers who attend injured motorcycle racers within minutes of an accident will often find the patient pale, clammy and with a difficult-to-palpate or absent pulse. This is often due to blood loss or other life-threatening injury but in some cases will resolve with no treatment & no significant bleeding or injury found. We propose that there is a significant release of catecholamines at the time of injury which results in severe vasoconstriction mimicking severe blood loss, injury or cardiac arrest.
We are in a fairly unique position in being able to attend severe trauma patients within minutes of their injury potentially allowing us to measure this. This study aims to see if there is a large release of adrenaline-like compounds during severe trauma that may mimic severe blood loss or cardiac arrest.
Who can participate?
Competitors in the 2025 Isle of Man TT who are injured during a race or practice session and require an intravenous cannula
What does the study involve?
Blood samples are obtained at the time of IV insertion and again when routine blood samples are taken on arrival in the Emergency department. This will be compared to the injury severity score to see if there is a relation between the two.
What are the possible benefits and risks of participating?
No obvious risks or benefits to participants
Where is the study run from?
Noble’s Hospital (Isle of Man)
When is the study starting and how long is it expected to run for?
May 2025 to June 2025
Who is funding the study?
Manx Care (Isle of Man)
Who is the main contact?
Dr David Frazer, David.Frazer@nobles.dhss.gov.im
Contact information
Public, Scientific, Principal Investigator
Emergency Department
Noble's Hospital
Strang
IM4 4RJ
Isle of Man
| Phone | +44 (0)1624650366 |
|---|---|
| david.frazer@gov.im |
Study information
| Study design | Quantitative single-centre pilot study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cross sectional study |
| Study setting(s) | Other |
| Study type | Diagnostic |
| Participant information sheet | Not available in web format |
| Scientific title | Pre-hospital measurement of catecholamine levels in injured motorcycle riders |
| Study objectives | There is a significant release of catecholamines at the time of injury, which results in severe vasoconstriction mimicking severe blood loss, injury or cardiac arrest. |
| Ethics approval(s) |
Approved 12/05/2025, Isle of Man Research Ethics Committee (Public Health Directorate Cabinet Office, Isle of Man Government, Douglas, IM4 4RJ, Isle of Man; +44 (0)1624 685765; adam.dempsey@gov.im), ref: 174 |
| Health condition(s) or problem(s) studied | Injured motorcycle riders |
| Intervention | Blood is taken as part of routine treatment and sent for additional testing to look at catecholamine levels. |
| Intervention type | Other |
| Primary outcome measure | Levels of metanepherines, metanepherine, 3-methoxytyramine and normetanepherine measured using blood test at arrival of prehospital treatment team and again on arrival at hospital |
| Secondary outcome measures | Severity of injury assessed using the Injury Severity Score at follow-up 1 month later |
| Overall study start date | 12/05/2025 |
| Completion date | 08/06/2025 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 30 |
| Key inclusion criteria | Competitors in the 2025 Isle of Man TT who are injured during a race or practice session and require an intravenous cannula |
| Key exclusion criteria | No significant injury |
| Date of first enrolment | 25/05/2025 |
| Date of final enrolment | 08/06/2025 |
Locations
Countries of recruitment
- Isle of Man
Study participating centre
Strang
IM4 4RJ
Isle of Man
Sponsor information
Hospital/treatment centre
Noble's Hospital
Strang
IM44RJ
Isle of Man
| Phone | +44 (0)1624650366 |
|---|---|
| Lesley.Clyde@nobles.dhss.gov.im | |
| Website | https://www.gov.im/about-the-government/statutory-boards/manx-care/ |
Funders
Funder type
Hospital/treatment centre
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Data sharing statement to be made available at a later date |
| Publication and dissemination plan | |
| IPD sharing plan | The data sharing plans for the current study are unknown and will be made available at a later date |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Protocol file | 23/05/2025 | No | No |
Additional files
Editorial Notes
23/05/2025: Study's existence confirmed by the Isle of Man Research Ethics Committee.
