Brain activation during sentence processing in Parkinson's disease: an event related functional magnetic resonance imaging study
| ISRCTN | ISRCTN18548326 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN18548326 |
| Protocol serial number | NTR782 |
| Sponsor | University of Groningen (The Netherlands) |
| Funder | Stichting Internationaal Parkinson Fonds (The Netherlands) |
- Submission date
- 28/12/2006
- Registration date
- 28/12/2006
- Last edited
- 04/11/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nervous System Diseases
Plain English summary of protocol
Not provided at time of registration
Contact information
Scientific
Oude Kijk int Jatstraat 26
Groningen
9712 EK
Netherlands
| Phone | +31 (0)50 363 8135 |
|---|---|
| k.s.f.colman@rug.nl |
Study information
| Primary study design | Observational |
|---|---|
| Study design | Observational case-control study |
| Secondary study design | Case-control study |
| Scientific title | |
| Study objectives | We hypothesise that basal ganglia (BG) are involved in sentence processing whenever a sentence structure deviates from the predicted structure and this in order to inhibit the irrelevant structure and to switch to a revision process. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Parkinson's disease |
| Intervention | No interventions. It is observational research with the use of functional magnetic resonance imaging (fMRI) (no use of invasive techniques). |
| Intervention type | Other |
| Primary outcome measure(s) |
For the fMRI analysis data, a main effect of group is expected. The level of activation in the BG will be reduced in the PD patient group compared to the healthy control group. For the within subject factors we expect to find a main effect of grammaticality. In the healthy elderly subject group, we expect that the processing of the grammatically incorrect sentences will activate the BG more compared to the processing of the grammatically correct sentences. For the behavioural data, we expect to find slower reaction times (RTs) for the processing of non-canonical ungrammatical sentences (i.e. passive sentences with a violation) in both subject groups. However the RTs will be significantly more affected in the PD group compared to the healthy elderly subject group. |
| Key secondary outcome measure(s) |
No secondary outcome measures |
| Completion date | 01/12/2007 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | All |
| Target sample size at registration | 32 |
| Key inclusion criteria | 1. Idiopathic Parkinson's disease (PD) 2. Hoehn and Yahr stage 1 to stage 3 3. Normal vision and hearing 4. Able to give informed consent 5. Older than 40 years 6. Dutch as first language 7. Right-handed 8. Normal structural magnetic resonance imaging (MRI) scan |
| Key exclusion criteria | 1. Not optimally medicated 2. Neurostimulator 3. Implanted pump (e.g. apomorphine) 4. Dementia (Mini Mental State Examination [MMSE] score less than 25) 5. Depression (Montgomery-Asberg Depression Rating Scale [MADRS] more than 18) 6. Another neurological disease 7. Another akinetic-rigid disorder 8. Another movement disorder 9. No normal structural MRI scan |
| Date of first enrolment | 01/12/2006 |
| Date of final enrolment | 01/12/2007 |
Locations
Countries of recruitment
- Netherlands
Study participating centre
9712 EK
Netherlands
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
