A study to investigate the effects of voluntary coughing on the airways of asthmatic and COPD subjects
| ISRCTN | ISRCTN57141601 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN57141601 |
| Protocol serial number | N0226187456 |
| Sponsor | Record Provided by the NHSTCT Register - 2007 Update - Department of Health |
| Funders | University Hospital of South Manchester NHS Foundation Trust, NWLC Endowment Funds, NHS R&D Support Funding |
- Submission date
- 28/09/2007
- Registration date
- 28/09/2007
- Last edited
- 07/06/2017
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Respiratory
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Record updated in last year
Plain English summary of protocol
Not provided at time of registration
Contact information
Dr Jaclyn Smith
Scientific
Scientific
University Hospital of South Manchester NHS Foundation Trust
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
United Kingdom
| Phone | +44 (0)161 291 5879 |
|---|---|
| jacky.smith@manchester.ac.uk |
Study information
| Primary study design | Interventional |
|---|---|
| Study design | Randomised controlled trial |
| Secondary study design | Randomised controlled trial |
| Study type | Participant information sheet |
| Scientific title | A study to investigate the effects of voluntary coughing on the airways of asthmatic and COPD subjects |
| Study objectives | To determine the effects of short bursts of voluntary coughing on airway physiology and lung function in asthmatic and COPD subjects. |
| Ethics approval(s) | Not provided at time of registration |
| Health condition(s) or problem(s) studied | Respiratory: Chronic obstructive pulmonary disease (COPD) |
| Intervention | Subjects will be randomised to either progressively increasing periods of voluntary coughing or no intervention, both interspersed with measurements of lung function. |
| Intervention type | Other |
| Primary outcome measure(s) |
The fall in exhaled nitric oxide (eNO) following voluntary coughing. |
| Key secondary outcome measure(s) |
No secondary outcome measures |
| Completion date | 30/10/2008 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Sex | All |
| Target sample size at registration | 20 |
| Key inclusion criteria | 1. Aged over 18 2. Physician diagnosed asthma or COPD |
| Key exclusion criteria | 1. Symptoms of upper respiratory tract infection or asthmatic/COPD exacerbation in the preceding 4 weeks 2. Involved in studies with licensed drugs or methodological studies within the preceding 4 weeks 3. Subjects taking ACE inhibitors, leukotrine receptor antagonists or cough suppressants 4. Change in asthma/COPD medication in last 4 weeks 5. Pregnancy 6. Current smokers |
| Date of first enrolment | 30/10/2006 |
| Date of final enrolment | 30/10/2008 |
Locations
Countries of recruitment
- United Kingdom
- England
Study participating centre
University Hospital of South Manchester NHS Foundation Trust
Manchester
M23 9LT
United Kingdom
M23 9LT
United Kingdom
Results and Publications
| Individual participant data (IPD) Intention to share | No |
|---|---|
| IPD sharing plan summary | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Participant information sheet | Participant information sheet | 11/11/2025 | 11/11/2025 | No | Yes |
Editorial Notes
07/06/2017: No publications found in PubMed, verifying study status with principal investigator.
