A study to investigate the effects of voluntary coughing on the airways of asthmatic and COPD subjects

ISRCTN	ISRCTN57141601
DOI	https://doi.org/10.1186/ISRCTN57141601
Secondary identifying numbers	N0226187456

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Record updated in last year

Plain English summary of protocol

Not provided at time of registration

Dr Jaclyn Smith
Scientific

University Hospital of South Manchester NHS Foundation Trust
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
United Kingdom

Phone	+44 (0)161 291 5879
Email	jacky.smith@manchester.ac.uk

Study design	Randomised controlled trial
Primary study design	Interventional
Secondary study design	Randomised controlled trial
Study setting(s)	Hospital
Study type	Treatment
Participant information sheet	Not available in web format, please use the contact details below to request a patient information sheet
Scientific title	A study to investigate the effects of voluntary coughing on the airways of asthmatic and COPD subjects
Study objectives	To determine the effects of short bursts of voluntary coughing on airway physiology and lung function in asthmatic and COPD subjects.
Ethics approval(s)	Not provided at time of registration
Health condition(s) or problem(s) studied	Respiratory: Chronic obstructive pulmonary disease (COPD)
Intervention	Subjects will be randomised to either progressively increasing periods of voluntary coughing or no intervention, both interspersed with measurements of lung function.
Intervention type	Other
Primary outcome measure	The fall in exhaled nitric oxide (eNO) following voluntary coughing.
Secondary outcome measures	No secondary outcome measures
Overall study start date	30/10/2006
Completion date	30/10/2008

Participant type(s)	Patient
Age group	Adult
Lower age limit	18 Years
Sex	Both
Target number of participants	10 stable mild asthmatic, 10 stable COPD subjects
Key inclusion criteria	1. Aged over 18 2. Physician diagnosed asthma or COPD
Key exclusion criteria	1. Symptoms of upper respiratory tract infection or asthmatic/COPD exacerbation in the preceding 4 weeks 2. Involved in studies with licensed drugs or methodological studies within the preceding 4 weeks 3. Subjects taking ACE inhibitors, leukotrine receptor antagonists or cough suppressants 4. Change in asthma/COPD medication in last 4 weeks 5. Pregnancy 6. Current smokers
Date of first enrolment	30/10/2006
Date of final enrolment	30/10/2008

University Hospital of South Manchester NHS Foundation Trust

Manchester
M23 9LT
United Kingdom

Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Government

The Department of Health
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom

Hospital/treatment centre

University Hospital of South Manchester NHS Foundation Trust

No information available

NWLC Endowment Funds

No information available

NHS R&D Support Funding

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

07/06/2017: No publications found in PubMed, verifying study status with principal investigator.